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The effect of energy content and protein concentration of a test meal and exercise intensity on the thermic effect of food (TEF) was examined. TEF was measured in eight men in response to meals representing 15, 30, and 45% of daily energy requirement; protein concentrations of 15, 30, and 45% of energy of the meal, and exercise intensities of 35, 50, and(More)
PURPOSE Progression to the castration-resistant state is the incurable and lethal end stage of prostate cancer, and there is strong evidence that androgen receptor (AR) still plays a central role in this process. We hypothesize that knocking down AR will have a major effect on inhibiting growth of castration-resistant tumors. EXPERIMENTAL DESIGN(More)
The blood in the carotid arteries exhibits time-varying flow velocity as a function of cardiac phases. Despite this flow velocity variation, most current methods set forth for the analysis of arterial spin labeling (ASL) data have assumed that the tagged blood is delivered from the tagging region to the imaging region via simple plug flow, i.e., a single(More)
Calmodulin is a substrate for the insulin receptor kinase. The time sequence of events resulting in insulin-stimulated phosphorylation of calmodulin was analyzed at a number of different insulin concentrations using partially purified solubilized insulin receptor preparations from rat adipocytes. The respective insulin concentrations needed to reach(More)
Some bacterial products possess multiple immunomodulatory effects and thereby complex mechanisms of action. Exogenous administration of an important Pseudomonas aeruginosa virulence factor, exoenzyme S (ExoS) induces potent monocyte activation leading to the production of numerous proinflammatory cytokines and chemokines. However, ExoS is also injected(More)
Calmodulin plays an important role in regulating cell proliferation and intranuclear processes (J. Biol. Chem. 265: 18595, 1990). Therefore we studied the association of 125I-calmodulin with highly purified rat hepatocyte nuclear preparations which were characterized by marker enzymes and electron microscopy. Steady-state association of 125I-calmodulin was(More)
Burkholderia pseudomallei has been shown to produce more than one capsular polysaccharide (CPS). Analysis of the B. pseudomallei genome has revealed that the organism contains four CPS operons (I-IV). One of these operons (CPS III) was selected for further study. Comparative sequencing analysis revealed that the genes encoding CPS III are present in B.(More)