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In recent years four mutations causing factor XI deficiency have been identified in Jews of Ashkenazi (European) origin. Two of them, type II (a nonsense mutation) and type III (a missense mutation), were found to prevail among 125 unrelated Ashkenazi Jews with severe factor XI deficiency. A finding of type II mutation in four unrelated Iraqi-Jewish(More)
130 women with postterm pregnancies (281-297 days of gestation) were examined with pulsed Doppler ultrasound of an umbilical artery. The result was not included in clinical decisions. In the group with abnormal flow a high rate of cesarean sections because of fetal distress (53%) was necessary, whereas only 3% were performed in the group with normal flow.(More)
OBJECTIVE The placental vascular architecture of small-for-gestational-age fetuses seems to have an impact on the flow patterns in the umbilical arteries. STUDY DESIGN Blood flow velocity waveforms of the umbilical arteries were measured by Doppler ultrasonography in nine small-for-gestational-age fetuses with elevated systolic/diastolic ratios of the(More)
Blood flow velocities of the umbilical arteries were measured by Doppler ultrasonography during variable decelerations of the fetal heart rate. The flow velocity waveforms, being normal between uterine contractions, showed either an unchanged flow velocity waveform with an exclusive fetal heart rate effect on end-diastolic velocities or a rapid change to(More)
For the first time, the rate of spontaneous abortion is reported in a multicenter study of three different gynecological centers. In 1987 und 1988, the average spontaneous abortion rate in 315 pregnancies was 3.3%, after foetal heart actions had been verified by ultrasonic examination between the 7th and 12th week of gestation. A statistical significance(More)
In 253 postterm pregnancies we investigated the correlation between retarded placental maturation, mode of delivery and fetal outcome and tried to answer the question, whether it is possible to estimate placental risk antenatal with pulsed doppler ultrasound of an umbilical artery. Villus maturation was determined by the criteria of Becker and the results(More)
In cases with different umbilical cord anomalies the influence of foetoplacental resistance on the flow velocity wave forms is discussed. If there is no anastomosis between the two umbilical arteries, the end-diastolic flow velocities depend on the volume of the foetoplacental vessel tree, i.e. higher resistance indices (RI) are found in the arteria with(More)
We studied 37 fetuses with absent or reverse end-diastolic flow velocities (AREDFV) of the umbilical arteries with respect to the mode of delivery, fetal acidosis, resistance index of the middle cerebral arteries, and abnormal neurological evaluation at the time of discharge from the department of pediatrics. A control group with normal umbilical artery(More)
Absent or reverse enddiastolic flow velocities (AREDFV) of the umbilical arteries are associated with fetal distress and adverse fetal outcome. We studied 68 fetuses with AREDFV with respect to abnormal neurological evaluation up to two years. A control group was matched for gestational age and had normal umbilical artery flow velocity waveforms. Fetuses(More)