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The V-D junctional residue at position 99 of AIJ anti-arsonate antibodies with a major cross-reactive idiotype is invariably a serine. This serine is not encoded in the germline of either the VH or DH gene segments nor can it be generated by intracodonic recombination between VH and DH. It must, therefore, be generated somatically (N segment addition) and(More)
It has been conjectured by Cowan and Emerson [3] that every graph has an unfriendly partition; i.e., there is a partition of the vertex set V= V, v V, such that every vertex of V, is joined to at least as many vertices in V, _, as to vertices in V,. It is easily seen that every rinite graph has such a partition, and hence by compact-ness so does any locally(More)
The nucleotide sequences of the coding as well as the flanking regions of 11 A/J J558 heavy chain variable region (VH) gene segments are presented. Among these J558 VH segments was the unrearranged germline VH gene segment recruited in the predominant A strain-specific anti-arsonate response. Three other VH gene segments that are greater than 92% related to(More)
A tournament .T = <T,-+> is a relational structure on the non-empty set T such that for x, y e T exactly one of the three relations x->y,x=y,y->x holds. Here x-+ y expresses the fact that {x, y} e-+ and we sometimes write this in the alternative form y <-x. Extending the notation to subsets of T we write A-+ B or B <-A if a-+ b holds for all pairs a, b with(More)
B cells of the largest Ig variable heavy chain gene (VH) family, VH3, are reportedly decreased in patients with late stage HIV-1 disease. This deficit may contribute to their impaired responses to infections and vaccines. We confirmed that the VH3 family was underrepresented in serum IgM proteins, with a 45% decrease in patients with advanced HIV-1 disease.(More)
The idiotypic cascade allows the induction of silent idiotypes, and as such, the immune system can be reprogrammed towards predetermined goals. To understand the genetic origin of silent idiotypes, we have used a system in which detailed structural and genetic information is available. The major cross-reactive idiotype (CRIA) of A/J mice (positive strain)(More)
Idiolypes have been implicated in the induction and regulation of complex humoral and cell-mediated immune phenomena. Now, with the development of hybridoma technology, the enigma of the molecular basis of idiotypy is succumbing to systematic serological and structural analyses. Here Don Capra and his colleagues describe recent studies on one of the best(More)
Anti-arsonate hybridoma antibodies of A/J mice have been grouped into 3 VH families by amino acid sequence analysis. One of these, the 91A3 family, which includes all CRI-positive molecules and some CRI-negative molecules, has been serologically defined by the presence of a VH marker (91A3 marker). Although the 91A3 family of antibodies is present at low(More)