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Phthalocyanines, porphyrin-like compounds with maximum absorption in the red, which were previously reported to localize selectively in tumours, have been shown to be efficient photosensitizers of mammalian cells in culture, thus making them possible candidates to replace haematoporphyrin derivatives in cancer phototherapy.
The photodynamic inactivation of retroviruses was investigated using aluminium and zinc phthalocyanine (Pc) derivatives. The N2 retrovirus packaged in either of the two murine cell lines, Psi2 and PA317, was used as a model for enveloped viruses. AlPc derivatives were found to be more effective photodynamically for inactivation of the viruses than the(More)
The objective of this study was to collect more information on the intricate relationship between the presence of a tumor, insulin status and blood lipids. We selected non-obese subjects suffering from colon, stomach and breast cancer and determined the concentration of fasting insulin, glucose, cholesterol, and triglycerides in blood before (BS) and after(More)
BACKGROUND AND OBJECTIVE When 5-aminolevulinic acid (ALA) is exogenously supplied, protoporphyrin IX (PpIX) is accumulated in various cells and makes them light sensitive. The possibility of using such an approach for the treatment of viral infections was studied in this work. STUDY DESIGN/MATERIALS AND METHODS ALA was added to cultured cells infected(More)
The photodynamic inactivation of herpes simplex virus type 1 (HSV-1) by two phthalocyanines (Pcs), the cationic dye HOSi-PcOSi(CH3)2(CH2)3N+(CH3)3I-(Pc5) and the amphiphilic dye aluminum dibenzodisulfophthalocyanine hydroxide (AlN2SB2POH), has been compared with that by the anionic dye, Merocyanine 540 (Mc540). Both Pc derivatives demonstrate a remarkable(More)
The antiviral photosensitization capacity of 11 different phthalocyanine (Pc) derivatives was examined using herpes simplex virus-1, herpes simplex virus-2 and varicella zoster virus in the search for the most potent sensitizers for viral decontamination of blood. The kinetics of viral photoinactivation were resolved during the stages of viral adsorption(More)