E. B. Maizel'

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A comparative study has been performed of effects of a natural chelator of transition metals, picolinic acid (PA) and of its structural analogues: nicotinic (NA), quinaldinic (QA), 2,6- and 3,4-pyridinedicarboxylic (2,6-PDCA, 3,4-PDCA) acids, as well as of synthetic chelators: EDTA and monoethanolaminediacetic acid (MEADAA), on dynamics of proliferation and(More)
Kinetic parameters of 9 substrates interaction with glutathione transferase (GST) from spring grain aphid and rat were studied. The most significant difference in Vmax values was noticed for 4-nitropyridine-N-oxide (6 times higher for aphid) and ethacrynic acid (7 times higher for rat). Km values were practically in all cases higher for aphid GST as(More)
At present, medicine employs preparations capable of inhibiting enzymes involved in the metabolism of xenobiotics; drugs of this type include, for example, iproniazid, imipramine, chlorcyclizine, and glutethimide [1, 2]. The purpose of this work was to synthesize Schiff bases from 4-aminopyrazolones, to synthesize hydrazones from nicotinic acid hydrazides(More)