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VNTR polymorphisms of the serotonin transporter (hSERT) and dopamine transporter (DAT1) gene were studied in male opiate addicts. Samples of ethnic Russians and ethnic Tatars did not differ in genotype and allele frequencies. Homozygosity at hSERT (especially 10/10) was associated with early opiate addiction, while genotype 12/10 proved to be protective. In(More)
The analysis of Msp1 polymorphism (-1438G/A) in the promoter region of serotonin receptor type 2A (5HTR2A) gene has been conducted using polymerase chain reaction method in the men with an acute alcoholic psychosis of Russian and Tartar nationalities. The results obtained indicate the 5HTR2A gene is involved in development of the given pathology and allow(More)
The PCR technique was used to analyze the TaqIA- and NcoI-polymorphisms at the dopamine D2 receptor gene (DRD2) in eight populations of the Volga-Ural region belonging to Turkic (Bashkirs, Tatars, and Chuvashes), Finno-Ugric (Maris, Komis, Mordovians, and Udmurts), and Eastern-Slavic (Russians) ethnic groups. Population-specific patterns of the main TaqIA-(More)
VNTR-polymorphism of the gene of dopamine transporter (DAT) in men of the Russian and Tatar nationalities with acute alcoholic psychoses was analyzed by method of the polymerase chain reaction. There were no differences in the distribution of frequencies of genotypes and alleles of DAT gene between the populations examined. There was association between an(More)
The polymerase chain reaction of DNA synthesis was used to analyze the polymorphism of TaqI A and NcoI loci of dopamine D2 receptor gene (DRD2) in 170 Tatar and Russian males with acute alcoholic psychosis. No differences were found in the distribution of frequencies of genotypes and alleles of DRD2 gene between the populations. There were differences in(More)
Insertion/deletion and VNTR polymorphisms of the serotonin transporter gene were tested for association with schizophrenia in patients varying in ethnicity. A difference in genetic predisposition was observed for continuous and shift-like schizophrenia forms, the former tending to be associated with genotype 12/12 in Tatars and L/L in Russians.
Polymorphism at the dopamine transporter gene (DAT1) in populations of the Volga-Ural region was examined by means of polymerase chain reaction. Statistically significant differences in the dopamine transporter gene allele and genotype frequency distribution were revealed both between the populations belonging to one ethnic group and between the populations(More)
The MspI restriction polymorphism of the serotonin 2A receptor gene (5HT2A) was typed in populations of the Volga-Ural region (Bashkirs, Chuvashes, Tatars, Udmurts, Maris, Mordovians, Komis, and Russians inhabiting the Republic of Bashkortostan). Population-specific patterns of the main polymorphism indices distribution were established. Specific trends in(More)
Population genetic survey of the indigenous populations of the Marii El Republic, represented by the two major ethnographic groups of Maris, Meadow (five samples from Morkinsk, Orshansk, Semursk, Sovetsk, and Zvenigovsk districts) and Mountain (one sample from Gornomariisk district) Maris, was carried out. All Mari groups were examined at nine polymorphic(More)
Polymorphism of the serotonin transporter gene (hSERT) was studied in eight human populations of the Volga-Ural region by means of polymerase chain reaction (PCR). The populations studied belonged to Turkic (Bashkirs, Tatars, and Chuvashes), Finno-Ugric (Maris, Komis, Mordovians, and Udmurts), and Eastern Slavic (Russians) ethnic groups. Comparison of the(More)