- Full text PDF available (0)
After chronic administration of pineal hormone melatonin (0.01 mg/kg) and amphetamine (0.05 mg/kg) of time-dependent conditional reflex was accelerated. Melatonin was more effective in this situation and its influence not accompanied with motor activation.
After chronic use of melatonin (3 mg before night-time for 14 days) campimetry showed a significant decrease of the threshold of brilliance sensitiveness of the retina in the absence of authentic changes of the sensorimotor response latency in individuals of the older age group. A connection between the eye light sensitivity and the direct effect of the… (More)
After bilateral lesion of dorsal hippocampus increase of the level of corticosterone and motility in night and decrease in daytime were observed.
Chronic administration of the pineal hormone melatonin in a low dose (0.75 mg) improved memory and optimized individual time perception in a group of young volunteers. These changes were pronounced even two weeks after termination of the drug administration. The expression of the melatonin effect was depended on the chronotype of humans tested.
The pineal hormone melatonin (0.1 mg/kg) produced a more pronounced antistressor effect as compared to the anxiolytic diazepam (same dose) in rats, which was manifested by decreased anxiety, improved heart rhythm variability, and prevented stress-induced violation of circadian locomotion. It is suggested that differences may result from more expressed… (More)
Pineal hormone melatonin, which is known to possess neuroptotector and nootrope activity, also produces a significant therapeutic effect with respect to various brain pathologies. The review of original and published data suggests that it is expedient to use melatonin in the treatment of cognitive disorders accompanying Parkinson's disease.
The reorganization of forced swimming time-course and behaviour in open field after superior cervical ganglionectomy in rats may be the result of disorders in adaptive processes. Behavioral shifts seem to be induced by the denervation of pineal gland with its adaptive properties. An increase of antidepressant drug (amitriptyline) activity was observed in… (More)
Agents with anxiolytic properties, namely, the tranquilizer diazepam (0.1 mg/kg), melatonin a hormone secreted by the pineal gland (0.1 mg/kg), and the beta-adrenergic blocker anapriline (5 mg/kg), remove in a similar manner stress-induced dysrhythmia in rats. Under their effect the circadian rhythm of motor activity is normalized and adaptation shifts in… (More)