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Reassessment of Exosome Composition
Myosin II functions in actin-bundle turnover in neuronal growth cones
This study reveals a mechanism for the regulation of actin-bundle length by myosin II that is dependent on actin -bundle severing, and demonstrates that retrograde flow is a steady state that depends on both myOSin II contractility and act in-network treadmilling.
A role for actin arcs in the leading-edge advance of migrating cells
It is proposed that net edge extension occurs by nascent focal adhesions advancing the site at which new actin arcs slow down and form the base of the next protrusion event, serving as a structural element underlying the temporal and spatial connection between the lamellipodium and the lamella during directed cell motion.
Bayesian localisation microscopy reveals nanoscale podosome dynamics
A localization microscopy analysis method that is able to extract results in live cells using standard fluorescent proteins and xenon arc lamp illumination and was able to reveal the nanoscale dynamics of podosome formation and dissociation throughout an entire cell with a resolution of 50 nm on a 4-s timescale.
Cytokinesis Monitoring during Development Rapid Pole-to-Pole Shuttling of a Signaling Protein by Localized Kinase and Phosphatase in Caulobacter
A contractile and counterbalancing adhesion system controls the 3D shape of crawling cells
A contractile actomyosin meshwork at the top of a cell is mechanically coupled to dorsal actin fibers that are anchored via focal adhesions to the cell surface, generating a counterbalanced…
Expansion and concatenation of nonmuscle myosin IIA filaments drive cellular contractile system formation during interphase and mitosis
Stacks of nonmuscle myosin IIA filaments form by the expansion of single filaments and concatenation of multiple filaments that are dependent on both motor activity and actin filament concentration.
Intraflagellar Transport Is Required for the Vectorial Movement of TRPV Channels in the Ciliary Membrane
Cell volume change through water efflux impacts cell stiffness and stem cell fate
- Ming Guo, A. Pegoraro, D. Weitz
- Biology, EngineeringProceedings of the National Academy of Sciences
- 25 September 2017
A robust and unified relationship between cell stiffness and cell volume is identified and it is found that changes in cell volume, and hence stiffness, alter stem-cell differentiation, regardless of the method by which these are induced.