Dustin R. Fraidenburg

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Chronic thromboembolic pulmonary hypertension (CTEPH) has been increasingly recognized as a common source of elevated pulmonary vascular resistance and pulmonary hypertension. It is clear that development of pulmonary thromboemboli is the inciting event for this process, yet it remains unclear why some patients have persistent pulmonary artery occlusion(More)
Gram-negative organisms comprise a large portion of the pathogens responsible for lower respiratory tract infections, especially those that are nosocomially acquired, and the rate of antibiotic resistance among these organisms continues to rise. Systemically administered antibiotics used to treat these infections often have poor penetration into the lung(More)
To the Editor: In the May issue of the Journal of Anesthesia, Demuro et al. [1] describe a case series of patients receiving dexmedetomidine for alcohol withdrawal. The authors highlight that benzodiazepines may be associated with hemodynamic instability and respiratory depression. An additional complication, intensive care unit (ICU) delirium, may be an(More)
Hypoxic pulmonary vasoconstriction (HPV) is an important physiological response that optimizes the ventilation/perfusion ratio. Chronic hypoxia causes vascular remodeling, which is central to the pathogenesis of hypoxia-induced pulmonary hypertension (HPH). We have previously shown that Notch3 is up-regulated in HPH and that activation of Notch signaling(More)
Pulmonary vascular remodeling, mainly attributable to enhanced pulmonary arterial smooth muscle cell proliferation and migration, is a major cause for elevated pulmonary vascular resistance and pulmonary arterial pressure in patients with pulmonary hypertension. The signaling cascade through Akt, comprised of three isoforms (Akt1-3) with distinct but(More)
An increase in cytosolic free Ca(2+) concentration ([Ca(2+)]cyt) in pulmonary arterial smooth muscle cells (PASMC) is a major trigger for pulmonary vasoconstriction and a critical stimulation for PASMC proliferation and migration. Previously, we demonstrated that expression and function of calcium sensing receptors (CaSR) in PASMC from patients with(More)
1 Pregnant women are susceptible to severe pneumonia and acute respiratory distress syndrome (ARDS) from influenza, which has been associated with increased fetal loss [1]. There is very little experience for the management of pregnant women with severe pneumonia and ARDS from avian influenza A (H7N9) virus, especially when complicated by intrauterine fetal(More)
Pulmonary vascular remodeling and increased arterial wall stiffness are two major causes for the elevated pulmonary vascular resistance and pulmonary arterial pressure in patients and animals with pulmonary hypertension. Cellular copper (Cu) plays an important role in angiogenesis and extracellular matrix remodeling; increased Cu in vascular smooth muscle(More)
Pulmonary arterial hypertension (PAH) remains a poorly understood disorder with dire consequences. Progression of disease often leads to right heart failure and death without lung transplantation. Limited therapeutic strategies exist for the treatment of PAH and current medical treatment consists of two major categories, supportive care therapeutics and(More)
Correspondence To the Editor: We would like to present Ramsay Hunt syndrome (RHS) as a complication of H7N9 influenza virus infection. On January 22, 2014, a 57‑year‑old man with a history of rheumatoid arthritis was admitted to the hospital complaining of dyspnea and fever. Infection with influenza A (H7N9) virus was confirmed from a tracheal aspirate(More)