Dusica Maysinger

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Unmodified cadmium telluride quantum dots induce reactive oxygen species formation leading to multiple organelle damage and cell death.

Jasmina Lovrić, Sung Ju Cho, Françoise M Winnik, Dusica Maysinger
Chemistry & biology
2005

Quantum dots (QDs) are luminescent nanoparticles with unique optical properties that have been exploited for single-cell and whole-animal imaging. When coated with proteins or biocompatible polymers,… (More)

Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets.

Reid Aikin, Dusica Maysinger, Lawrence Rosenberg
Endocrinology
2004

Therapeutic strategies aimed at the inhibition of specific cell death mechanisms may increase islet yield and improve cell viability and function after routine isolation. The aim of the current study… (More)

Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots

Jasmina Lovrić, Hassan S Bazzi, Yan Cuie, Genevieve R. A. Fortin, Françoise M Winnik, Dusica Maysinger
Journal of Molecular Medicine
2004

Quantum dots (QDs) are emerging as alternative or complementary tools to the organic fluorescent dyes currently used in bioimaging. QDs hold several advantages over conventional fluorescent dyes… (More)

Long-term exposure to CdTe quantum dots causes functional impairments in live cells.

Sung Ju Cho, Dusica Maysinger, Manasi P Jain, Beate Roeder, Steffen Hackbarth, Françoise M Winnik
Langmuir : the ACS journal of surfaces and…
2007

Several studies suggested that the cytotoxic effects of quantum dots (QDs) may be mediated by cadmium ions (Cd2+) released from the QDs cores. The objective of this work was to assess the… (More)

Block copolymer micelles: preparation, characterization and application in drug delivery.

Geneviève Gaucher, Marie-Hélène Dufresne, Vinayak Sant, Ning Kang, Dusica Maysinger, Jean-Christophe Leroux
Journal of controlled release : official journal…
2005

Block copolymer micelles are generally formed by the self-assembly of either amphiphilic or oppositely charged copolymers in aqueous medium. The hydrophilic and hydrophobic blocks form the corona and… (More)

Differential effects of acute and chronic ethanol treatment on particular opioid peptide systems in discrete regions of rat brain and pituitary

Bernd R. Seizinger, K. Bovermann, Dusica Maysinger, Volker Hoellt, A. Herz
Pharmacology Biochemistry and Behavior
1983

Acute ethanol treatment induced a significant increase in the tissue levels of immunoreactive (ir-) Met-enkephalin in hypothalamus, striatum and midbrain, but not in hippocampus. Levels of… (More)

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

Lars Groth Grunnet, Reid Aikin, +7 authors Thomas Mandrup-Poulsen
Diabetes
2009

OBJECTIVE Proinflammatory cytokines are cytotoxic to beta-cells and have been implicated in the pathogenesis of type 1 diabetes and islet graft failure. The importance of the intrinsic mitochondrial… (More)

Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells

Angela On-Ki Choi, Sung Ju Cho, Julie Desbarats, Jasmina Lovrić, Dusica Maysinger
Journal of nanobiotechnology
2007

BACKGROUND Neuroblastoma, a frequently occurring solid tumour in children, remains a therapeutic challenge as existing imaging tools are inadequate for proper and accurate diagnosis, resulting in… (More)

Quantum dot cytotoxicity and ways to reduce it.

Françoise M Winnik, Dusica Maysinger
Accounts of chemical research
2013

The dramatic increase in the use of nanoparticles (NP) in industry and research has raised questions about the potential toxicity of such materials. Unfortunately, not enough is known about how the… (More)

Cell loss in isolated human islets occurs by apoptosis.

Steven Paraskevas, Dusica Maysinger, Richard D. Wang, T P Duguid, Lawrence Rosenberg
Pancreas
2000

Purified islet allografts have largely failed to maintain long-term glucose homeostasis in human recipients, and the reasons for this are unclear. It is noteworthy, however, that islet isolation… (More)

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