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The recent Zika virus outbreak highlights the need for low-cost diagnostics that can be rapidly developed for distribution and use in pandemic regions. Here, we report a pipeline for the rapid design, assembly, and validation of cell-free, paper-based sensors for the detection of the Zika virus RNA genome. By linking isothermal RNA amplification to toehold(More)
Executive Summary This document establishes a new child-specific health guidance value (HGV) for lead, for use in health risk assessment at school sites pursuant to Health and Safety Code Section 901(g). This HGV is a benchmark incremental change in blood lead concentration (ΔPb B) of 1 microgram lead per deciliter (µg/dl) of blood. More specifically, this(More)
Protein-protein interactions (PPIs) play crucial roles in diverse cellular processes. There are different types of PPIs based on the composition, affinity and whether the association is permanent or transient. Analyzing the diversity of PPIs at the atomic level is crucial for uncovering the key features governing the interactions involved in PPI. A(More)
Synthetic biology aims to create functional devices, systems, and organisms with novel and useful functions taking advantage of engineering principles applied to biology. Despite great progress over the last decade, an underlying problem in synthetic biology remains the limited number of high-performance, modular, composable parts. A potential route to(More)
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