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The only small-molecule compound demonstrated to substantially extend survival in prion-infected mice is a biaryl hydrazone termed "Compd B" (4-pyridinecarboxaldehyde,2-[4-(5-oxazolyl)phenyl]hydrazone). However, the hydrazone moiety of Compd B results in toxic metabolites, making it a poor candidate for further drug development. We developed a pharmacophore(More)
There is not a single pharmaceutical that halts or even slows any neurodegenerative disease. Mounting evidence shows that prions cause many neurodegenerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best therapeutic targets. We report here that the previously identified 2-aminothiazoles IND24 and IND81 doubled the(More)
  • Duo Lu
  • Methods in molecular biology
  • 2012
Fluorescence anisotropy is a useful tool to detect SSB interaction with SSB binding partners. Titrating an SSB protein partner into a solution containing fluorescently labeled SSB C-terminal tail (SSB-Ct) peptide results in formation of the protein complex with molecular weights greatly higher than SSB peptide alone. Thus the tumbling of the complexes in(More)
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