Dunina-Barkovskaya AYa

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Weak acids are efficient blockers of gap-junctional conductance. It is generally accepted that intracellular acidification produced by weak acids fully accounts for the gap-junctional uncoupling. Protonation of the cytoplasmic portions of the channel-forming protein connexin is thought to lead to the conformational changes switching the channel from the(More)
Current views on the molecular mechanisms of the pH dependence of gap junctions are mainly based on the experimental fact that extracellularly applied CO2 or other weak acids rapidly and reversibly block junctional conductance and also decrease intracellular pH. Data are presented suggesting that the mechanism of the uncoupling action of weak acids may be(More)
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