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  • Dung Thai, Jo Ellen Dyer, Peyton Jacob, Christine Haller
  • Medicine
  • Clinical pharmacology and therapeutics
  • 2007 (First Publication: 1 February 2007)
  • 1,4-Butanediol (BD) is converted to gamma-hydroxybutyrate (GHB) after ingestion, and is associated with cases of dependence, coma, and death. The pharmacology of BD after oral ingestion has not beenExpand
  • S. Verstovsek, M. Savona, +4 authors J. Gotlib
  • Medicine
  • 2015 (First Publication: 3 December 2015)
  • Background: Simtuzumab (SIM) is a humanized monoclonal antibody that inhibits lysyl oxidase-like molecule 2 (LOXL2), an extracellular matrix enzyme that catalyzes the covalent cross-linking ofExpand
    75Background: Andecaliximab (ADX) is a monoclonal antibody that inhibits matrix metalloproteinase 9 (MMP9). Preclinical studies suggest that MMP9 inhibition relieves immune suppression and promotesExpand