Duncan W Blake

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BACKGROUND AND METHODS The use of cocaine, especially one of its alkaloidal forms ("crack"), has been increasingly associated with cerebrovascular disease. To clarify the clinical, radiologic, and pathological features of the events associated with cocaine use, we identified 28 patients at four medical centers who had stroke temporally related to the use of(More)
OBJECTIVE To examine the relation between rate of synovial membrane enhancement, intra-articular pressure (IAP), and histologically determined synovial vascularity in rheumatoid arthritis, using gadolinium-DTPA enhanced magnetic resonance imaging (MRI). METHODS Dynamic gadolinium-DTPA enhanced MRI was performed in 31 patients with knee synovitis (10(More)
UNLABELLED Accurate detection of atheroma within the thoracic aorta is an important part of most stroke prevention strategies in cardiac surgery. The thoracic aorta was divided into six zones corresponding to sites of surgical manipulation. Zones 1-3, proximal, mid and distal ascending aorta, zones 4-5, proximal and distal arch and zone 6, proximal(More)
This multi-centre, parallel group, randomized, double-blind study compared the efficacy and safety of high-dose remifentanil administered by continuous infusion with an intermittent bolus fentanyl regimen, when given in combination with propofol for general anaesthesia in 321 patients undergoing elective coronary artery bypass graft surgery. A significantly(More)
A new classification is described to improve precision of thoracic atheroma reporting. In 68 patients, the thoracic aorta was screened with epiaortic and transesophageal echocardiography. The thoracic aorta is divided into 6 zones corresponding to sites of aortic manipulation. Zones 1-3, proximal, mid and distal ascending aorta, Zones 4-5, proximal and(More)
BACKGROUND Postoperative pain may be severe after coronary artery bypass surgery. High thoracic epidural analgesia (HTEA) provides intense analgesia. METHODS Eighty patients were randomized to HTEA or intravenous morphine analgesia (control). Patients received coronary artery bypass surgery (CABG) with cardiopulmonary bypass. Pain was measured by visual(More)
Patients scheduled for elective surgery requiring general anaesthesia and hospital admission were assessed for risk of obstructive sleep apnoea (OSA) using history, body mass index and upper airway examination to determine any relation between OSA risk and the rate of respiratory events after surgery. Anaesthesia and postoperative analgesia were at the(More)
UNLABELLED alpha(2)-Adrenoreceptor agonists may counteract the increased basal sympathetic nervous activity in patients with congestive heart failure (CHF), but they may also compromise reflex responses to hypovolemia. We have tested responses to simulated hemorrhage (central hypovolemia) after IV dexmedetomidine in normal animals and in experimental(More)
The effects of i.v. infusions of althesin, ketamine and thiopentone were studied in instrumental rabbits, in doses that produced similar levels of light anesthesia. The main hemodynamic differences were in the rises in mean arterial pressure (MAP) and in total peripheral resistance (TPR) which were in the order of ketamine greater than thiopentone greater(More)
This study assessed the agreement between three methods of cardiac output (CO) measurement, thermodilution, the current clinical standard, and two transoesophageal echocardiographic techniques. Measurements were performed in 37 patients using thermodilution, continuous wave Doppler across the aortic valve and pulsed wave Doppler positioned in the left(More)