Duncan Macrae

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BACKGROUND Meningococcal disease is still associated with considerable mortality, despite the use of early antibiotics and management in specialised intensive care units, due principally to early refractory myocardial depression and hypotension as well as severe acute respiratory distress syndrome. Extracorporeal membrane oxygenation (ECMO) is a complex(More)
BACKGROUND Although mechanical circulatory support might not increase the number of adults surviving to transplantation, because of the shortage of donor organs, the situation might be different for children. Our aim was to assess the effect of mechanical assist devices to bridge children with end-stage cardiomyopathy to heart transplantation. METHODS A(More)
We obtained audiograms and auditory brainstem responses from 44 patients with Duane's retraction syndrome to assess the incidence and nature of hearing deficit. Of 44 patients, seven (15.9%) had evidence of hearing impairment. Three (6.8%) subjects had a temporary conductive hearing loss because of middle ear fluid, and another patient had hearing loss from(More)
Cardiovascular Cardiac failure: epidemiology and treatment Mebazaa and colleagues in two interesting papers [1, 2] described the clinical presentation, management, and outcomes of acute heart failure (AHF) through the Acute Heart Failure Global Survey of Standard Treatment (ALARM-HF) on AHF conducted in nine countries in four continents. In the first paper(More)
Intracranial pressure and brain compliance in traumatic brain injury Elevated intracranial pressure (ICP) has been associated with increased mortality in patients with severe traumatic brain injury (TBI). More than 20 years ago, Marmarou [1], while analysing the data from the traumatic coma data bank (TCDB), recognized that the proportion of hourly ICP(More)
Acute renal injury Acute renal failure (or acute kidney injury, AKI) is an important issue in critical care because, as was demonstrated in the past, the patients' prognosis is dependent on the disturbed renal function. In 2010, four interesting reviews were presented dealing with general, but also with some specific issues of AKI in critically ill(More)