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Everolimus is a novel inhibitor of the mammalian target of rapamycin pathway, which is aberrantly activated in cancer cell. We conducted a phase I study of capecitabine plus everolimus (RAD001) in refractory gastric cancer patients. Patients with metastatic gastric cancer and progression after prior chemotherapy were eligible. Four dose levels were planned(More)
Diffuse large B-cell lymphoma (DLBCL) constitutes most primary central nervous system (CNS) lymphoma (PCNSL), whereas T-cell, low-grade and Burkitt’s lymphomas (BL) are rarely encountered. Due to the paucity of cases, little is known about the clinical features and treatment outcomes of PCNSL other than DLBCL. The objective of this study was to describe the(More)
The case of a 37-year-old man with carpal tunnel syndrome and a palpable mass in the proximal wrist is reported. Roentgenograms revealed an old middle-third scaphoid fracture with the proximal pole displaced into the proximal carpal tunnel. Excision of this mass led to a complete resolution of the patient's carpal tunnel problem.
A 23-year-old man had two recurrences following local excision of a hemangiopericytoma of the right orbit. A third local excision was followed by a course of postoperative radiation therapy (64.8 Gy [6480 rad] in 36 treatments). Seven and a half years following therapy, the patient is disease free and has experienced no side effects.
The aim of this phase I study was to investigate the optimal dose of S-1 and oxaliplatin with concurrent radiotherapy in a preoperative setting for locally advanced gastric cancer. Twelve patients with histologically confirmed clinical stage T2N+ or T3–T4 gastric adenocarcinoma received dose level −1 (oral S-1 at 60 mg/m2/day + oxaliplatin 40 mg/m2(More)
OBJECTIVE Pediatric-type sarcomas such as Ewing's sarcoma (EWS)/primitive neuroectodermal tumor family and rhabdomyosarcoma are relatively uncommon in adult patients. Optimal treatment strategies for this population and prognosis in adult patients compared with pediatric patients remain controversial. METHODS We retrospectively reviewed pediatric-type(More)
The purpose of the study was to evaluate the efficacy and tolerability of S-1 monotherapy in metastatic colorectal cancer (CRC) patients who have failed the standard oxaliplatin-based or irinotecan-based chemotherapy. From 2007 to 2010, metastatic CRC patients who received S-1 monotherapy as salvage treatment were identified from tumor registry at Samsung(More)
Copyright © 2013 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly(More)