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Several studies indicate a role for toll-like receptors (TLRs) in the pathogenesis of systemic lupus erythematosus (SLE). We aimed to investigate the risk of SLE and typical clinical and serological manifestations of SLE potentially conferred by selected single nucleotide polymorphisms (SNPs) of genes encoding TLR7, TLR8, and TLR9. Using a multiplexed(More)
BACKGROUND The objective was to assess crude 5-year delivery rates after assisted reproductive technology (ART) treatment, intrauterine inseminations (IUI), spontaneous conceptions (SC) and adoptions in a large infertile cohort. METHODS A prospective longitudinal survey comprised 1338 infertile couples starting public infertility programmes offering IUIs(More)
Low vitality (a component of fatigue) in middle-aged and older adults is an important complaint often identified as a symptom of a disease state or side effect of a treatment. No studies to date have investigated the potential link between dysfunctional mitochondrial ATP production and low vitality. Therefore, we measured a number of cellular parameters(More)
OBJECTIVES To investigate tobacco and alcohol consumption as risk indicators for missing teeth in late middle-aged Danes. METHOD In all, 1,517 Copenhagen Aging and Midlife Biobank (CAMB) participants received a clinical oral examination that included number of teeth. Information on smoking, drinking, and various covariates was obtained using(More)
BACKGROUND Bullying among children is associated with high symptom load and depression. There is little knowledge about long-term consequences of bullying. The aim of the present study is to examine the association between recall of bullying at school and depression in midlife controlling for adult social class and parents' mental health. METHODS The(More)
BACKGROUND Most studies on disclosure of mode of conception after fertility treatment have focused on donor insemination. We present a large, longitudinal cohort study of fertility patients who conceived through a variety of fertility treatments, including both non-donor and donor techniques. METHODS A cohort of 2812 women and men (n = 1406 couples)(More)
OBJECTIVE The objective of the present study is to analyze gender differences and social class gradients in physical functions; and to study whether the social class gradients in physical functions in midlife differed between men and women. METHOD This study used traditionally used physical performance tests and we added several tests of vigorous physical(More)
OBJECTIVE The aim of the article is to analyze associations between sex, age, education, and social class and cognitive ability in late midlife and to evaluate differences in cognitive ability among the three Copenhagen Aging and Midlife Biobank (CAMB) cohorts. METHOD The sample comprised 5,417 CAMB participants from three cohorts with scores on the(More)