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Pol II and its associated epigenetic marks are present at pol III-transcribed non-coding RNA genes
Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (PolExpand
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Stb3 Plays a Role in the Glucose-Induced Transition from Quiescence to Growth in Saccharomyces cerevisiae
Addition of glucose to quiescent Saccharomyces cerevisiae cells causes the immediate induction of ∼1000 genes. These genes include ribosomal proteins (RP) and non-RP genes needed for ribosomeExpand
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The protein histidine phosphatase LHPP is a tumour suppressor
Histidine phosphorylation, the so-called hidden phosphoproteome, is a poorly characterized post-translational modification of proteins. Here we describe a role of histidine phosphorylation inExpand
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The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma
ABSTRACT The cell's repertoire of transfer RNAs (tRNAs) has been linked to cancer. Recently, the level of the initiator methionine tRNA (tRNAiMet) in stromal fibroblasts has been shown to influenceExpand
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Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas
RNA polymerase III (Pol-III) transcribes tRNAs and other small RNAs essential for protein synthesis and cell growth. Pol-III is deregulated during carcinogenesis; however, its role in vivo has notExpand
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Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs
Significance Organisms maintain a constant level of blood glucose. mTOR, an atypical serine/threonine kinase, plays a major role in glucose metabolism. This is evident in mouse models whereExpand
Colitis is associated with loss of LHPP and up-regulation of histidine phosphorylation in intestinal epithelial cells
Protein histidine phosphorylation (pHis) is a posttranslational modification involved in cell cycle regulation, ion channel activity and phagocytosis (1). Using novel monoclonal antibodies to detectExpand