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Millions of patients suffer from major depressive disorder (MDD), but many do not respond to selective serotonin reuptake inhibitor (SSRI) therapy. We used a pharmacometabolomics-informed pharmacogenomics research strategy to identify genes associated with metabolites that were related to SSRI response. Specifically, 306 MDD patients were treated with(More)
The initial decades of the twenty-first century have witnessed striking technical advances that have made it possible to detect, identify and quantitatively measure large numbers of plasma or tissue metabolites. In parallel, similar advances have taken place in our ability to sequence DNA and RNA. Those advances have moved us beyond studies of single(More)
brings together undergraduates and faculty in mathematics, statistics, and the life sciences to work in interdisciplinary research clusters. In the following, Drew Neavin, a CSU biology major and participant in this program, describes an ongoing FEScUE project based on research in the lab of CSU Biochemsitry Professor Jeff Hansen. Genetic research has been(More)
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