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Distribution and Phylogeny of EFL and EF-1α in Euglenozoa Suggest Ancestral Co-Occurrence Followed by Differential Loss
Background The eukaryotic elongation factor EF-1α (also known as EF1A) catalyzes aminoacyl-tRNA binding by the ribosome during translation. Homologs of this essential protein occur in all domains ofExpand
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Malleable mitochondrion of Trypanosoma brucei.
The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list of necessary mitochondrial processes is steadily growing. Here, we summarize the current knowledge ofExpand
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Architecture of the trypanosome RNA editing accessory complex, MRB1
Trypanosoma brucei undergoes an essential process of mitochondrial uridine insertion and deletion RNA editing catalyzed by a 20S editosome. The multiprotein mitochondrial RNA-binding complex 1 (MRB1)Expand
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Unusual mitochondrial genome structures throughout the Euglenozoa.
Mitochondrial DNA of Kinetoplastea is composed of different chromosomes, the maxicircle (bearing 'regular' genes) and numerous minicircles (specifying guide RNAs involved in RNA editing). InExpand
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Probing for primary functions of prohibitin in Trypanosoma brucei.
Prohibitins (PHBs) 1 and 2 are small conserved proteins implicated in a number of functions in the mitochondrion, as well as in the nucleus of eukaryotic cells. The current understanding of PHBExpand
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A Core MRB1 Complex Component Is Indispensable for RNA Editing in Insect and Human Infective Stages of Trypanosoma brucei
Uridine insertion/deletion RNA editing is a unique and vital process in kinetoplastids, required for creation of translatable open reading frames in most mitochondrially-encoded RNAs. Emerging as aExpand
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Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing.
Trypanosoma brucei is the causative agent of the human and veterinarian diseases African sleeping sickness and nagana. A majority of its mitochondrial-encoded transcripts undergo RNA editing, anExpand
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Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei.
A majority of Trypanosoma brucei proteins have unknown functions, a consequence of its independent evolutionary history within the order Kinetoplastida that allowed for the emergence of severalExpand
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Description of Rhynchopus euleeides n. sp. (Diplonemea), a Free‐Living Marine Euglenozoan
ABSTRACT. We describe Rhynchopus euleeides n. sp., using light and electron microscopy. This free‐living flagellate, which was isolated earlier from a marine habitat, can be grown axenically in aExpand
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Phylogeny and Morphology of New Diplonemids from Japan.
Diplonemids were recently found to be the most species-rich group of marine planktonic protists. Based on phylogenetic analysis of 18S rRNA gene sequences and morphological observations, we reportExpand
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