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- Publications
- Influence
Distribution and Phylogeny of EFL and EF-1α in Euglenozoa Suggest Ancestral Co-Occurrence Followed by Differential Loss
- Gillian H. Gile, Drahomíra Faktorová, +5 authors P. Keeling
- Biology, Medicine
- PloS one
- 9 April 2009
Background The eukaryotic elongation factor EF-1α (also known as EF1A) catalyzes aminoacyl-tRNA binding by the ribosome during translation. Homologs of this essential protein occur in all domains of… Expand
Malleable mitochondrion of Trypanosoma brucei.
- Zdeněk Verner, S. Basu, +13 authors J. Lukeš
- Biology, Medicine
- International review of cell and molecular…
- 2015
The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list of necessary mitochondrial processes is steadily growing. Here, we summarize the current knowledge of… Expand
Architecture of the trypanosome RNA editing accessory complex, MRB1
- M. Ammerman, Kurtis M Downey, +7 authors L. K. Read
- Biology, Medicine
- Nucleic acids research
- 6 March 2012
Trypanosoma brucei undergoes an essential process of mitochondrial uridine insertion and deletion RNA editing catalyzed by a 20S editosome. The multiprotein mitochondrial RNA-binding complex 1 (MRB1)… Expand
Unusual mitochondrial genome structures throughout the Euglenozoa.
- J. Roy, Drahomíra Faktorová, J. Lukeš, G. Burger
- Biology, Medicine
- Protist
- 18 July 2007
Mitochondrial DNA of Kinetoplastea is composed of different chromosomes, the maxicircle (bearing 'regular' genes) and numerous minicircles (specifying guide RNAs involved in RNA editing). In… Expand
Probing for primary functions of prohibitin in Trypanosoma brucei.
- Jiří Týč, Drahomíra Faktorová, +4 authors J. Lukeš
- Biology, Medicine
- International journal for parasitology
- 2010
Prohibitins (PHBs) 1 and 2 are small conserved proteins implicated in a number of functions in the mitochondrion, as well as in the nucleus of eukaryotic cells. The current understanding of PHB… Expand
A Core MRB1 Complex Component Is Indispensable for RNA Editing in Insect and Human Infective Stages of Trypanosoma brucei
- M. Ammerman, Danielle L. Tomasello, +4 authors L. K. Read
- Medicine, Biology
- PloS one
- 18 October 2013
Uridine insertion/deletion RNA editing is a unique and vital process in kinetoplastids, required for creation of translatable open reading frames in most mitochondrially-encoded RNAs. Emerging as a… Expand
Integrity of the core mitochondrial RNA-binding complex 1 is vital for trypanosome RNA editing.
- Zhenqiu Huang, Drahomíra Faktorová, +4 authors H. Hashimi
- Biology, Medicine
- RNA
- 1 December 2015
Trypanosoma brucei is the causative agent of the human and veterinarian diseases African sleeping sickness and nagana. A majority of its mitochondrial-encoded transcripts undergo RNA editing, an… Expand
Functional characterization of two paralogs that are novel RNA binding proteins influencing mitochondrial transcripts of Trypanosoma brucei.
- L. Kafková, M. Ammerman, +6 authors H. Hashimi
- Medicine, Biology
- RNA
- 1 October 2012
A majority of Trypanosoma brucei proteins have unknown functions, a consequence of its independent evolutionary history within the order Kinetoplastida that allowed for the emergence of several… Expand
Description of Rhynchopus euleeides n. sp. (Diplonemea), a Free‐Living Marine Euglenozoan
- J. Roy, Drahomíra Faktorová, O. Benada, J. Lukeš, G. Burger
- Biology, Medicine
- The Journal of eukaryotic microbiology
- 1 March 2007
ABSTRACT. We describe Rhynchopus euleeides n. sp., using light and electron microscopy. This free‐living flagellate, which was isolated earlier from a marine habitat, can be grown axenically in a… Expand
Phylogeny and Morphology of New Diplonemids from Japan.
- Daria Tashyreva, Galina Prokopchuk, +9 authors J. Lukeš
- Biology, Medicine
- Protist
- 21 February 2018
Diplonemids were recently found to be the most species-rich group of marine planktonic protists. Based on phylogenetic analysis of 18S rRNA gene sequences and morphological observations, we report… Expand