Dragoslav Milosević

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The aim of this work was to investigate T cell subset composition of peripheral blood cells in patients with acute myeloid leukaemia, acute lymphoblastic and chronic lymphocytic leukaemia, by enumerating T cells positive for receptors for sheep erythrocytes (E-RFC, A-RFC) using the method of E-rosette, and for CD3, CD4 and CD8 antigens, by indirect(More)
The effect of neonatal extirpation of the interscapular brown adipose tissue (adipectomy) on the development of experimental allergic thyroiditis in 8-week-old inbred Lewis rats was studied. The incidence and intensity of disease were much higher, and delayed skin reactions significantly stronger, in adipectomized rats than in control sham-adipectomized(More)
Analysis of T lymphocyte subsets made a great progress in attempting their important role in host defence against malignant disease. As the major regulatory elements in the immune system, helper (CD4+) and suppressor (CD8+) T cells are required for recognizing a large scale of surface antigen on tumor cells and subsequently, for mediating the regression of(More)
The authors report seven cases of Richter's syndrome, i.e. of large-cell non-Hodgkin's lymphoma (NHL) arising in association with chronic lymphocytic leukemia (CLL). Six patients had the recently recognized variant of this syndrome, occurring in patients with previously undiagnosed subclinical CLL. All patients were treated with aggressive chemotherapy and(More)
Irradiation is the conventional treatment modality for cancer patients. However, besides its cytotoxic effects on malignant cells it might also affect the biology of surviving cells. Since overexpression of HER-2 receptors on malignant cells is a prerequisite for the therapeutic efficacy of Herceptin, it seems important to know whether previous irradiation(More)
BACKGROUND Several studies showed that PGE-mediated immunosuppression in cancer patients may be differentially affected by conventional oncologic therapy. METHODS Since there is little evidence about the action of immunotherapy on this suppression mechanism, we investigated the effect of therapy with a thymic agent-T-activin, on in vitro modulation of(More)
We investigated the clinical and immunological effects of T-activin therapy in early stage melanoma patients. Several immune parameters (the number of T cells-E-RFC and CD3+, their subsets-CD4+ and CD8+, the number of CD38+ and CD16+ cells, and mitogen-induced lymphoproliferative response-LPR) were analyzed in relation to the clinical course of the disease(More)
  • D Milosević
  • Journal of experimental & clinical cancer…
  • 2000
Multiple cell surface receptors play an important role in the biology of hematological malignant cells. Like already clustered monoclonal antibodies, the use of new markers of differentiation provide some new information about their structure and function. Here we consider the role of few selected regulatory proteins that are most frequently involved in the(More)