Dragoș Florea

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AIM The study aimed to evaluate the clinical utility of the chemiluminescent HCV core Ag test compared to viral load assessment in the management of patients with chronic hepatitis C. METHODS A retrospective study was performed at a tertiary-care infectious diseases hospital on samples collected from anti-HCV positive patients. Seventy-six samples were(More)
Background Since 2011 a rapid increase of cases with Clostridium difficile infection (CDI) was observed in the National Institute for Infectious Diseases (NIID), the largest tertiary level infectious diseases hospital in Romania. The need of a fast and accurate diagnosis of CDI and the low sensitivity of the available rapid immunoassays supported the(More)
OBJECTIVES We analysed the distribution of vaccine and non-vaccine Streptococcus pneumoniae serotypes and the antimicrobial susceptibility of pneumococcal strains isolated from healthy Romanian children. METHODS A multi-centre cross-sectional study was performed in four counties to evaluate carried strains of S. pneumoniae isolated from 2000 children aged(More)
Methods We collected data for all 398 confirmed or probable cases of CDI admitted during 15 November 2013-28 February 2014 in 11 hospitals: 5 from Bucharest, and 7 from Cluj, Iaşi, Timişoara, Târgu Mureş and Braşov. PCR ribotyping was performed at Cantacuzino Institute and E-test (for moxifloxacin and metronidazole) and binary toxin gene identification(More)
Methods A cohort, retrospective study was conducted in Adult Clinic I of the National Institute for Infectious Diseases “Prof. Dr. Matei Balş”, Bucharest, over a 6 year-period (01.2008-12.2013). The main inclusion criteria were: HIV-positive patients stable on ART (>6 months) at their first regimen, good adherence and absence of other medication susceptible(More)
Case report An overview of our 2011-2013 experience retrieved several common mistakes of CDI management (e.g. almost 51% of CDI patients received combined therapy with metronidazole and vancomycin, less than 25% colectomies for cases with toxic megacolon, several secondary cases in patients hospitalized in the same room with a non-diagnosed CDI patient). We(More)
BACKGROUND The need to limit the spread of drug-resistant Mycobacterium tuberculosis requires rapid detection of resistant strains. The present study aimed to evaluate a commercial assay using broad-range PCR coupled with electrospray ionization mass spectrometry (PCR/ESI-MS) for the rapid detection of isoniazid (INH) and rifampin (RIF) resistance in M.(More)
A1 The outcome of patients with recurrent versus non-recurrent pneumococcal meningitis in a tertiary health-care hospital in Bucharest Cristian-Mihail Niculae, Eliza Manea, Raluca Jipa, Simona Merisor, Ruxandra Moroti, Serban Benea, Adriana Hristea National Institute for Infectious Diseases “Prof. Dr. Matei Balș”, Bucharest, Romania; Carol Davila University(More)