Dr. med. Marco M. Schneider

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BACKGROUND In patients with ovarian carcinoma, an hematocrit-independent hyperviscosity syndrome is often present. The syndrome is characterized by normal or low hematocrit and hemoglobin concentration, an elevated platelet count, and an increase in clotting factor turnover. Because deep vein thrombosis (DVT) often complicates the course of ovarian(More)
The use of platinum based chemotherapy in ovarian malignancy and other cancer types is known to be associated with deep vein thrombosis. In a prospective study of 47 patients with ovarian cancer of International Federation of Gynecology and Obstetrics stage Ib-IV, serial rheological parameters were determined (plasma viscosity, red blood cell aggregation(More)
Ovarian cancer cells appear to be capable of both thrombin formation and induction of fibrin degradation which may be essential prerequisites for the development of deep vein thrombosis (DVT) as well as the spread of malignancy. To study further this coagulation-cancer interaction in 60 patients with untreated ovarian cancer of FIGO stage I-IV the incidence(More)
Prophylaxis of thromboembolism with low molecular mass (LMM) heparin may offer several advantages over conventional heparin during pregnancy. Heparin-related side effects as osteoporosis, local allergy, thrombocytopenia and increase in liver enzymes may occur less frequently with LMM heparin. However, LMM heparins of different origins have to be considered(More)
Prophylaxis of thromboembolism in pregnancy with low molecular weight heparin (LMWH) offers several advantages over conventional heparin (UFH) including the once daily application and the reduction of heparin-related side effects like osteoporosis, thrombocytopenia and allergy. Until now the use of LMWH in obstetrics failed because of a possible placental(More)
A recently identified mechanism for familial thrombophilia--the poor anticoagulant response to activated protein C (APC-resistance)--is said to be one of the leading risk factors for thrombosis. This has been demonstrated by a large number of studies. But there is still a need for data concerning the prevalence of APC-resistance in pregnancy. Therefore we(More)