Dr. med. Astrid Zobel

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Excess comorbidity between depression and epilepsy proposes common pathophysiological patterns in both disorders. Neuroendocrine abnormalities were often observed in depression as well as in epilepsy. Lack of inhibitory control of the hypothalamic pituitary adrenocortical (HPA) system is a core feature of depression; main relay stations of this system are(More)
Das Konzept "Endophänotyp" hat in der psychiatrischen Genetik derzeit eine hohe Popularität. Die gegenwärtigen Schwierigkeiten bei der Suche nach Suszeptibilitätsgenen für komplexe Erkrankungen wird auf die ätiologische Heterogenität des klinischen, psychopathologisch definierten Krankheitsphänotyps zurückgeführt. Neurobiologische Krankheitskorrelate, die(More)
Schizophrenia and affective disorder have been considered to be nosologically and etiologically distinct disorders. This postulate is challenged by progress in new biological research. Both disorders are strongly influenced by genetic factors; thus genetic research is a main contributor to this discussion. We review current evidence of the genetic(More)
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