Dr. Wolfgang Muller

Learn More
Results of recent studies have suggested that routine cardiac catheterization may be unnecessary after reperfusion therapy for acute myocardial infarction. Therefore to better define the short-term prognostic value of early coronary angiography, and specifically the prognostic significance of multivessel coronary artery disease, the angiographic findings of(More)
To determine whether complex cardiovascular interventional procedures (including coronary stent implantation, directional atherectomy, aortic valvuloplasty, and the use of an intraaortic balloon pump or cardiopulmonary bypass support) are associated with an increased likelihood of vascular access site complications, 2,400 consecutive cardiac catheterization(More)
BACKGROUND Interleukin-8 (IL-8), a CXC chemokine that induces the migration and proliferation of endothelial cells and smooth muscle cells, is a potent angiogenic factor that may play a role in atherosclerosis. Previously, IL-8 has been reported in atherosclerotic lesions and circulating macrophages from patients with atherosclerosis. Therefore, we sought(More)
The adjunctive use of intravenous captopril with tissue plasminogen activator early during acute myocardial infarction offers theoretic advantages of diminishing left ventricular volume, preventing ventricular dilation and improving patient survival. To test the safety and efficacy of combined early administration of intravenous captopril and recombinant(More)
We describe 2 patients with Takayasu's arteritis and left main coronary stenosis who were considered poor candidates for surgical revascularization. Elective left main coronary artery balloon angioplasty followed by endoluminal stenting was performed with excellent results. At 3-mo follow-up, one patient had evidence of in-stent restenosis, but the other(More)
OBJECTIVES This study was designed to characterize the clinical, echocardiographic and angiographic findings in patients who have regional wall motion abnormalities predictive of coronary artery disease on dobutamine stress echocardiograms, although coronary angiography reveals no critical stenoses. BACKGROUND The specificity of dobutamine stress(More)
BACKGROUND Site-directed pharmacologic therapy using drug-impregnated polymers may achieve high local tissue levels at sites of arterial injury without systemic side effects. The aim of this study was to determine whether sustained, local administration of the synthetic glucocorticoid dexamethasone reduces the severity of intimal hyperplasia induced by(More)
Activated clotting time (ACT) and activated partial thromboplastin time (APTT) are used for monitoring heparin therapy during coronary angioplasty. The purpose of this study was to determine which parameter is more useful clinically, and to assess the correlation between ACT and APTT. The authors measured these parameters at fixed intervals (0, 15, 30, 60,(More)
Doppler tissue imaging (DTI) is a new noninvasive imaging modality that directly interrogates myocardial velocity with high temporal and spatial resolution. This study was designed to test the hypothesis that quantitative DTI provides unique information regarding regional myocardial systolic and diastolic function during acute ischemic events. Myocardial(More)
BACKGROUND The efficacy of aorto-coronary vein grafting is limited by early graft thrombosis and accelerated graft atherosclerosis. Direct adenovirus-mediated transfer of genes encoding inhibitory proteins may prevent or slow progression of vein graft disease. METHODS AND RESULTS Recombinant adenoviruses containing the cDNA for the marker gene lacZ(More)