Dr. S. Beer

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Food additive butylated hydroxytoluene (BHT) (CAS: 128-37-0; 2,6-di-tert-butyl-p-cresol) can modulate the formation of lung adenomas in mice treated with the carcinogen urethan (CAS: 51-79-6; ethyl ester carbamic acid). An ip injection of BHT administered 6 hours before a single urethan injection decreased the number of tumors formed, whereas six weekly BHT(More)
Butylated hydroxytoluene (BHT) causes transient lung damage in mice, and it can either inhibit or enhance carcinogen induction of tumors in internal organs, such as urethan-induced lung adenomas. Since protein kinase C (Pk-C) may mediate the action of one class of tumor-modulatory agents, the phorbol esters which promote skin tumorigenesis, we are examining(More)
The cyclic adenosine 3':5'-monophosphate (cAMP)-dependent protein kinases in lung adenomas are functionally different from those of normal lung. The relevance of this change to neoplastic conversion was examined by comparing tumor kinases with those obtained from the normal cell of origin and by studying the kinases at different stages of tumor growth. Lung(More)
No cAMP-dependent protein kinase activity is found upon DEAE-cellulose chromatography of mouse fat extracts at the low salt concentration characteristic of the Type I isozyme. The RI detected in fat extracts by photoincorporation of the analog, 8-N3 [32P]cAMP, elutes within the high salt Type II isozyme peak. The multiple charge variants of this(More)
Die multiple Sklerose (MS) ist eine komplexe Erkrankung mit heterogener Pathologie und sehr variablem klinischem Verlauf. Durch den progredienten multisystemischen Befall des zentralen Nervensystems entstehen komplexe Störungsbilder und Behinderungen. Trotz medikamentöser krankheitsmodifizierender Therapien und symptomatischer Behandlungen ist bei einem(More)
Fewer lung adenomas were induced by urethan in BALB/cBy mice than in the A/J or SWR/J mouse strains. When BALB mice were crossed with either of these more sensitive strains the response of the progeny to urethan was most easily explained by a single gene which regulates susceptibility, with the more resistant phenotype behaving as a dominant trait. C56BL/6J(More)
Sirs: Patients with fibrocartilaginous embolisation of the spinal cord develop a vascular myelopathy after usually minor traumatic events without major bony lesions of the vertebral bodies, typically with a symptom-free intervall [1, 2]. It is assumed, that a high axial disc load causes fragments of the nucleus pulposus to be injected into arterioles and(More)
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