Dr. L. Söhngen

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We investigated platelet function of 21 healthy blood donors before, 4 hrs and 1 to 7 days after a single oral dose of 0.02 (n = 3), 0.05 (n = 3), 0.1 (n = 3), 0.5 (n = 2) and 1.0 g (n = 10) aspirin. Three additional donors received 0.02 g aspirin/day for 5 days. A new and simple in vitro bleeding test (Thrombostat) using whole blood was far more sensitive(More)
In the Federal Republic of Germany fresh-frozen plasma (FFP) is still the most important therapeutic agent for acquired coagulation disorders. However, thawing by waterbath (WB) requires about 30 minutes, which is too slow in emergency situations and carries the risk of bacterial contamination of the FFP. There are conflicting data about the use of(More)
We report here on a new multiple bag system with top and bottom drainage of the primary bag which allows automatic separation of blood components on a routine basis. 100 units of 450 ml fresh whole blood (CPD) were centrifuged by hard spin centrifugation and then separated into leukocyte-poor red cell concentrates in additive solution (volume 284 +/- 22 ml,(More)
The in-vitro-bleeding-test (IVBT) is able to detect sensitively the disorders of platelet function. They are frequently caused by von-Willebrand-syndrome or aspirin. In 7.4% of our thrombocytapheresesis donors the IVBT was abnormal. The plasmatic coagulation has no influence on the IVBT.
Eight thrombocytopenic/pathic patients received an intravenous infusion of phospholipids. In-vitro-bleeding test, thrombelastography and resonance thrombography were performed in order to show the hemostatic effect. There was no case in which phospholipids had an efficacy comparable to the transfusion of platelets. Two patients suffered from a severe(More)
Eight thrombocytopenic/pathic patients received an intravenous infusion of phospholipids. In vitro bleeding test (Thrombostat 4000), thrombelastography, and resonance thrombography were performed in order to show the hemostatic effect. In none of the cases did phospholipids exert an effect comparable to platelet transfusion. Two patients, brother and(More)
Summarizing several studies, it can be shown that the new cell separator AS-104 (Fresenius), in comparison to the older systems, provides a real advantage concerning the separation efficiency, the purity of the platelet concentrates (PC), the platelet function and the donor safety. The results of 5 different separation protocols demonstrate the technical(More)
Ist eine Gebärmutterentfernung aus medizinischen Gründen indiziert oder besteht der Wunsch nach sicherer Beschwerdefreiheit, werden zur Vermeidung einer abdominellen Hysterektomie (HE) heutzutage bevorzugt die vaginale HE sowie laparoskopisch assistierte Verfahren, wie die totale laparoskopische Hysterektomie (TLH), die laparoskopisch assistierte(More)
Cytaphereses are safe and can be used routinely like whole blood donations on the premise that standard techniques based on appropriate guidelines and regulations are performed. Before the introduction of a new cell or plasma separator, a thorough clinical investigation is always recommended in order to demonstrate biocompatibility and safety features. In(More)