Dr. Konrad Zucker

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Rats were treated with kainic acid (KA) i.v. to produce increasingly severe limbic seizures that were monitored with a behavioral rating scale. At various times after the induction of seizures, the animals; blood-brain barriers (B-BB) were studied with alpha-[14C]aminoisobutyric acid ([14C]AIBA) autoradiography. Using optical density ratios, a coefficient(More)
Because available evidence suggests that alterations in the serotonergic as well as dopaminergic tones underlie hallucinatory activity, we decided to investigate whether serotonin and dopamine pathways are modified in alcoholics with a history of hallucinosis. Brain serotonin has been shown to depend on the plasma ratio of its precursor tryptophan over(More)
Studies, carried out in generalized populations, have shown inverse relationships between degree of religiosity and attitudes towards drinking, knowledge about alcohol, amount of alcohol consumed, and physical complications of alcohol abuse. Within a population of chronic male alcoholics, we found that the more religious patients had a more anti-alcohol(More)
Although an association of psychiatric symptoms with vitamin B12 deficiency is well accepted, the incidence and nature of these symptoms is not established. To help illuminate the natural history of this illness we review the literature regarding psychopathology associated with B12 deficiency and examine 15 cases, including one of our own, that meet(More)
Alcoholic blackouts are among the most frequently reported symptoms in the progression of alcoholism. The exact etiology of blackouts remains unknown, but relationships to memory disturbance, seizure disorders, underlying psychiatric conditions, head trauma, and drug use have all been suggested. We studied 72 alcoholics admitted to an alcohol inpatient(More)
Alcohol has been observed to alter various aspects of memory function. Some of the most extreme forms of memory impairment experienced by alcoholics are blackouts. There are at present very few data on the biological mechanisms underlying alcohol-related memory impairment. A variety of mechanisms including the cholinergic and catecholaminergic systems have(More)