Dr. Harold O. Conn

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In a double-blind, randomized study the efficacy of lactulose was compared with neomycin-sorbitol in 45 episodes of acute nitrogenous portal-systemic encephalopathy (PSE) induced by dietary protein, azotemia, or gastrointestinal hemorrhage. All patients had underlying cirrhosis, and at the time of randomization had encephalopathy of at least grade 2(More)
Previous reports from this hospital in 1958 and 1967 have revealed that esophageal tamponade is a relatively dangerous type of treatment. Other investigators have been able to avoid many of the hazards of this technique. We have again assessed our results in 50 episodes of esophageal tamponade in bleeding esophageal varices in 39 patients. Thirty-seven had(More)
Leukopenia, thrombocytopenia, and hemolytic anemia occur commonly in advanced cirrhosis. Some investigators have reported that portacaval anastomosis (PCA) abolishes hypersplenism while others have not found PCA to be uniformly beneficial. We compared the frequency of hypersplenism before and after admission to a controlled investigation of the effects of(More)
In order to determine the composition of “normal” ascitic fluid, the results of analysis of the first paracentesis on 347 consecutive cirrhotic patients with ascites at the West Haven Veterans Administration Hospital between 1955 and 1976 were examined. The ascites was considered “normal” in 259 patients. Bacterial peritonitis was present in 51, malignant(More)
The frequency of diabetes, defined as persistent fasting hyperglycemia, was evaluated in a consecutive group of 240 cirrhotic patients. A randomly selected group of 411 noncirrhotic patients of similar age, admitted to the hospital during the same period, served as a control group. Diabetes was significantly more common in the cirrhotic group (40 of 240,(More)
Conventional tests to determine the patency of portacaval anastomoses (PCA) are indirect, inferential, and inaccurate. Superior mesenteric arteriography and percaval catheterization of the portal vein are two direct methods of evaluating shunt patency. Thirty-four patients who had had PCA constructed 6 months to 12 years previously had superior mesenteric(More)
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