Dr. F. Rarl Roth

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Migration and proliferation of smooth muscle cells (SMC) from the media into the subendothelial space are important steps in the development of restenosing events after angioplasty; therefore a medical inhibition of this activity seems to be of clinical interest. Primary stenosing plaque material of 20 patients and restenosing plaque material of 6 patients(More)
BACKGROUND Transfilter culture systems with enzymatically isolated human vascular cells were established to imitate the morphologic situation of the inner parts of a vessel wall. METHODS In transfilter cultures, only smooth muscle cells were seeded on one side of the filter, whereas in transfilter cocultures, smooth muscle cells were cultivated in the(More)
BACKGROUND Restenosis after successful percutaneous transluminal coronary angioplasty remains the major clinical problem limiting the long-term efficacy of the treatment. Recent advances in the understanding of the biology of restenosis indicate that its cause is predominantly a multifactorial stimulation of smooth-muscle cell proliferation. The aim of this(More)
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By cultivating smooth muscle cells, isolated from media-pieces of rabbit and human aorta, on microporous filter membranes (transfilter-culture-system), it is possible to examine proliferation and migration of smooth muscle cells at the same time. After addition of Epinephrine to the cultures, an increase in proliferation and migration was observed.
With enzymatically isolated smooth muscle cells from primary stenosing lesions cultured in a transfilterculturesystem it is possible to examine multiple steps (e.g. migration and proliferation) involved in the development of restenosing lesions at the same time. By using human atherosclerotic plaque material the clinical relevance of experiments might be(More)