Dr. E. Bonucci

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The organic-inorganic relationships in bone matrix undergoing osteoclastic resorption have been studied in rat tibial diaphyses using electron microscope techniques in an attempt to identify the steps of the resorption process. Results suggest that bone resorption occurs in two phases: the first, an extracellular phase, leads to bone matrix fragmentation(More)
The resorption of the uncalcified cartilage matrix of the middle third of the diaphysis in the chick embryo tibia has been studied using histological, histochemical and electron microscopic techniques. The first stage in the resorption process affects the periosteal bone, which is breached by osteoclasts at one or several points. Capillary vessels and(More)
Folliculin administration to pigeons stimulates the development of medullary bone in marrow spaces of the femora and other long bones. It is a specialized osseus tissue not devoted to mechanical functions and which is rapidly reabsorbed before egg-shell formation. Medullary bone is formed and reabsorbed in the same way as other types of bone. Consequently,(More)
Two direct technical approaches have been developed in order to establish the density of three types of isolated microscopic structures of bone tissue. The average density of material from osteoid tissue has been found to be 1.46 by employing the isopicnic centrifugation technique in a CsCl-water gradient. The density of cylindrical osteones has been(More)
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