Dr.Dinesh M. Sakarkar

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High performance thin layer chromatographic method is developed for simultaneous estimation of ibuprofen and pseudoephedrine hydrochloride in tablets. Silica gel 60F(254) plates were used as stationary phase and t.butanol: ethyl acetate: glacial acetic acid: water (7:4:2:2 v/v) as mobile phase. Wavelength selected for analysis was 254 nm. Percent estimation(More)
The aim of the present study was to study the effect of chronic treatment (9 weeks) of fluoxetine (20 mg/kg p.o.) a selective serotonin reuptake inhibitor on blood glucose level and in prevention of diabetic neuropathic pain perception. Evaluation of diabetic neuropathy was performed after 9 weeks of single injection of streptozotocin (70 mg/kg i.v.) in(More)
Isolated preparat ion are commonly used to study the effect of drugs on specific type of recep tor, fo r b ioassay of d rug , fo r characterization of specific type of receptor or i ts subtypes , for pharmacokinet ic s tudy, to de te rmine concent ra t ion response curve of agonist, to study the antagonism of drug and in new drug discovery (1). The(More)
Two simple, accurate and precise spectrophotometric methods have been developed for simultaneous determination of nitazoxanide and ofloxacin in tablets. Method I is Q-absorbance ratio method which involves Q-absorbance at isobestic point (306.25 nm) and max (347.5 nm) of nitazoxanide, while method II is two wavelength method, where 244.6 nm and 273.0 nm(More)
Wound healing potential of different extracts of henna leaves i.e. Lawsonia inermis Linn. was evaluated on the rat excision and incision wound models. Lawsone isolated from the leaves was also screened for same pharmacological activity.It was observed that the oral administration as well as topical application of ethanol extract of henna leaves and lawsone(More)
BACKGROUND The purpose of present investigation to isolate β-sitosterol diglucosyl caprate from the rhizomes of Alpinia galanga. METHODS The methanolic extract of the rhizomes of plant Alpinia galanga was subjected to column chromatography and was eluted with ethyl acetate-methanol (99:1) to yield compound (AG5) β-sitosterol diglucosyl caprate. Various(More)
The last few decades have hosted a revolution in materials science. In many cases, it is now possible to manipulate atoms and molecules within materials one at a time and, therefore, to construct materials with nanometer-scale precision. This new capability in materials science is called nanotechnology. The potential intersection between nanotechnology and(More)
OBJECTIVE To explore the effects of extract of Hibiscus rosasinensis (H. rosasinensis) on the volume, free and total acidity of gastric secretion induced by carbachol. METHODS Animals were kept on fasting for 48 h, then the pylorus of each animal was ligated. They were randomly divided into 5 groups and treated by carbachol at 600 μg/kg. Then animals in(More)
Use of lipids as commonly used excipients like emulsifiers; base for semisolid preparations such as ointments, creams; as flow modifiers for granule preparations in tablet making are known since ages in formulation technology. But researchers are looking at the application of lipids in drug delivery from a different facet. Much of research is now focused on(More)
In the present investigation, an attempt has been made to increase therapeutic efficacy, reduce frequency of administration, and improve patient compliance, by developing sustained release matrix tablets of diclofenac sodium using natural polymers such as Xanthan gum, locust bean gum, sodium alginate. Sustained release matrix tablets of diclofenac sodium,(More)