Dr. D. Alvaro

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We investigated whetherS-adenosyl-l-methionine (SAMe) influences the inhibitory effect of ethanol on bile secretion and ethanol hepatotoxicity in the isolated perfused rat liver. SAMe (25 mg/kg intramuscularly three times a day) was administered for three days consecutively. Liver was then isolated and perfused with taurocholate to stabilize bile secretion(More)
The oral administration of 0.4% taurine in drinking water for 14 consecutive days showed the following hepatic effects in male guinea pig. The percentage of tauro-conjugated biliary bile acids was increased from 17.2–54.2%; the ratio liver weight/body weight was increased, and fatty change was induced. Liver triglyceride concentration was accordingly(More)
We investigated whether S -adenosyl-L-methionine(SAMe), dilinoleoylphosphatidylcholine (DLPC), or SAMe+ DLPC influence liver lipid composition as well asacute ethanol hepatotoxicity in the isolated perfused rat liver (IPRL). SAMe (25 mg/kgintramuscularly three times a day) was administered forfive consecutive days, while DLPC was(More)
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