Dr. A. G. Macdonald

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BACKGROUND Prophylactic surgical treatment of the neck in "early tongue tumors" is a controversial issue. METHODS From a database of 226 patients with squamous cell carcinoma of the tongue treated at Canniesburn Hospital, Glasgow, U.K., between 1980 and 1996, a total of 137 patients with a minimum follow up of 24 months or until death were clinically(More)
A recent preliminary report of a study to determine the patterns of invasion of squamous cell carcinoma to the nonirradiated edentulous mandible indicated that tumor entered mainly through the residual alveolar occlusal ridge. This study has now been extended and includes both nonirradiated and irradiated mandibles. Of a total of 46 nonirradiated mandibles(More)
The patterns of spread of squamous cell carcinoma within the mandible were investigated in 43 nonirradiated (33 edentulous and 10 partially dentate) and 16 irradiated mandibles. Two modes of spread were identified: (1) spread in relation to the inferior alveolar nerve, and (2) spread in spaces between cancellous bony trabeculae. Although nerve-related(More)
BACKGROUND Debate continues over the management of the N0 neck in head and neck malignancy. Therefore, the possibility of performing sentinel node biopsy in these patients was investigated to formulate a method for the procedure. METHODS Patients undergoing prophylactic or therapeutic neck dissections were injected with either Patent Blue V dye alone or(More)
BACKGROUND Sentinel lymph node (SLN) biopsy originally was described as a means of identifying lymph node metastases in malignant melanoma and breast carcinoma. The use of SLN biopsy in patients with oral and oropharyngeal squamous cell carcinoma and clinically N0 necks was investigated to determine whether the pathology of the SLN reflected that of the(More)
A series of 21 cases of adenomatoid odontogenic tumour is reported from Sri Lanka. They formed 8.6% of odontogenic tumours, excluding odontomes, in the 10-year period reviewed. 85% of cases occurred in the anterior maxilla. Most cases were diagnosed clinically as dentigerous cysts. There were no recurrences following conservative surgery in follow-up(More)
OBJECTIVE To investigate the possible role of sentinel node biopsy (SNB) alone to upstage the clinically N0 neck in patients with oral and oropharyngeal squamous cell carcinoma. DESIGN Prospective clinical study. SETTING Head and neck referral center. PATIENTS Patients with primary untreated oral and/or oropharyngeal squamous cell carcinoma accessible(More)
This study aimed to evaluate the ability of lymphoscintigraphy (LSG) to direct sentinel node biopsy (SNB) in the identification of occult metastases in the clinically N0 neck for patients with head and neck squamous cell carcinoma (HNSCC). 57 clinically N0 neck sides in 48 patients were assessed using the triple diagnostic approach of pre-operative LSG,(More)