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Stressful events during gestation and in the neonatal period have important effects on the later physical and mental health of the offspring. The present study tested the hypothesis that pre- and/or postnatal stress would affect seizure susceptibility in infant and adult rats, using the hippocampal kindling model. Prenatal stress consisted of daily(More)
Atherosclerosis develops in distinct regions of the arterial tree. Defining patterns and mechanisms of endothelial cell gene expression in different regions of normal arteries is key to understanding the initial molecular events in atherogenesis. In this study, we demonstrated that the expression of endothelial nitric-oxide synthase (eNOS), an(More)
Atherosclerosis is a complex disease process in which monocytes and lymphocytes are recruited from the blood into the arterial intima. Mouse models of atherosclerosis have been developed, carefully characterized and used to elucidate molecular mechanisms of atherosclerotic lesion formation. Deficiency of various chemokines, chemokine receptors and leukocyte(More)
Mass transfer between flowing blood and arterial mural cells (including vascular endothelial cells) may play an important role in atherogenesis. Endothelial cells are known to have an apical surface topography that is not flat, and hence mass transfer patterns to individual endothelial cells are likely affected by the local cellular topography. The purpose(More)
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