Douglas Walker

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The Australian E-Health Research Centre, CSIRO ICT Centre, Brisbane, Queensland, Australia School of Information Technology & Electrical Engineering, University of Queensland, Brisbane, Queensland, Australia School of Human Movement Studies, University of Queensland, Brisbane, Queensland, Australia Wesley Medical Imaging, Brisbane, Queensland, Australia(More)
The importance of carbohydrate recognition in biology, and the unusual challenges involved, have lead to great interest in mimicking saccharide-binding proteins such as lectins. In this review, we discuss the design of artificial carbohydrate receptors, focusing on those which work under natural (i.e. aqueous) conditions. The problem is intrinsically(More)
This study presents a novel method for the automatic segmentation of the quadratus lumborum (QL) muscle from axial magnetic resonance (MR) images using a hybrid scheme incorporating the use of non-rigid registration with probabilistic atlases (PAs) and geodesic active contours (GACs). The scheme was evaluated on an MR database of 7mm axial images of the(More)
Early-onset bipolar disorder (BD) is often misdiagnosed and inadequately treated because of the varying constellation of symptoms that occur across different developmental stages, the variety of disorders with similar presentation, and the frequent comorbidities. The etiology of BD is complex, but research confirms the major role that genetics and(More)
A synthetic approach to rotaxane architectures is described in which metal atoms catalyze covalent bond formation while simultaneously acting as the template for the assembly of the mechanically interlocked structure. This "active-metal" template strategy is exemplified using the Huisgen-Meldal-Fokin Cu(I)-catalyzed 1,3-cycloaddition of azides with terminal(More)
A route to mechanically interlocked architectures that requires only a catalytic quantity of template is described. The strategy utilizes the Cu(I)-catalyzed 1,3-cycloaddition of azides with terminal alkynes. Chelating the Cu(I) to an endotopic-binding macrocycle means that the metal atom binds to the alkyne and azide in such a way that the metal-mediated(More)
Both single and multigrain U-Pb zircon thermal ionization mass spectrometry (TIMS) as well as sensitive high resolution ion microprobe (SHRIMP ll) dating of two suites of Adirondack granites have yielded ages constraining the principal tectonomagmatic events of the Ottawan Orogeny to the interval ca 1090–1035 Ma. The earliest of these consists of mildly(More)
Carbohydrate recognition mediates a wide range of biological processes, including protein folding and trafficking, cell– cell recognition, infection by pathogens, and many aspects of the immune response. Molecules capable of selective carbohydrate binding are, therefore, valuable as tools for biological research, and potentially as medicinal agents. There(More)