Douglas R. Anderson

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Evidence from electrophysiological studies has suggested an inhibitory interaction between GABAergic neurons in substantia nigra pars reticulata and dopaminergic neurons in pars compacta. However, that this inhibitory interaction is due to a projection from pars reticulata to pars compacta has never been demonstrated directly, nor has the GABAergic neuron(More)
PURPOSE To determine the effects of age, optic disc area, ethnicity, eye, gender, and axial length on the retinal nerve fiber layer (RNFL) in the normal human eye as measured by Stratus OCT (optical coherence tomography). DESIGN Cross-sectional observational study. PARTICIPANTS Three hundred twenty-eight normal subjects 18 to 85 years old. METHODS(More)
Tritiated leucine was injected into the vitreous of owl monkeys (Aotus trivirgatus) to make it available to retinal ganglion cells for protein synthesis. Intraocular pressure was maintained for eight hours at selected levels between 15 and 105 mm. Hg. Autoradiography and scintillation counting were used to follow the movement of the labeled protein along(More)
PURPOSE OF REVIEW Before this study was done, there was a difference of opinion concerning whether intraocular pressure (IOP) was involved in producing optic nerve damage when there was glaucomatous damage to the optic nerve and characteristic visual field loss, even though the IOP was in the statistically normal range. This article reviews the findings of(More)
Let (E,Σ) be a pair of spaces consisting of a compact Hausdorff space E and a closed subspace Σ. Let A be an additive category. This paper introduces the category B(E,Σ;A) of geometric modules over E with coefficients in A and with continuous control at infinity. One of the main results is to show that the functor that sends a CW comples X to the algebraic(More)
PURPOSE To determine the ability of optic nerve head (ONH) parameters measured with spectral domain Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, CA) to discriminate between normal and glaucomatous eyes and to compare them with the discriminating ability of peripapillary retinal nerve fiber layer (RNFL) thickness measurements performed with Cirrus(More)
A general mathematical theory of line transects is develoepd which supplies a framework for nonparametric density estimation based on either right angle or sighting distances. The probability of observing a point given its right angle distance (y) from the line is generalized to an arbitrary function g(y). Given only that g(O) = 1, it is shown there are(More)
Glaucoma is now considered an abnormal physiology in the optic nerve head that interacts with the level of intraocular pressure (IOP), with the degree and rate of damage depending on the IOP and presumably the degree of abnormal physiology. Diagnosis of normal-tension glaucoma (NTG), defined as glaucoma without a clearly abnormal IOP, depends on recognizing(More)
The glaucomas are a group of relatively common optic neuropathies, in which the pathological loss of retinal ganglion cells causes a progressive loss of sight and associated alterations in the retinal nerve fiber layer and optic nerve head. The diagnosis and management of glaucoma are often dependent on methods of clinical testing that either, 1) identify(More)