Douglas McIlroy

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CAD (caspase-activated DNase) can cause DNA fragmentation in apoptotic cells. Transgenic mice that ubiquitously express a caspase-resistant form of the CAD inhibitor (ICAD) were generated. Thymocytes prepared from the mice were resistant to DNA fragmentation induced by a variety of stimuli. However, similar numbers of TUNEL-positive cells were present in(More)
To determine the interaction between the gag precursor and the viral protease and to confirm the role of gag precursor in formation of human immunodeficiency virus type 1 particles, the gag and protease encoding regions of a proviral genome with mutations at the site between p17 and p24 or p24 and p15 were expressed by recombinant baculoviruses under the(More)
Degradation of chromosomal DNA into nucleosome-sized fragments is one of the characteristics of apoptotic cell death. Here, we examined whether caspase-activated DNase (CAD) is responsible for the DNA fragmentation that occurs upon exposure to various apoptotic stimuli. When human Jurkat cells were exposed to etoposide, or UV or gamma radiation, a(More)
In this paper we describe the development of the Mental Health-Patient Information Management System (MH-PIMS), which is an information management system designed for use in a modern, primarily community-based, mental health service. MH-PIMS is a computerised database which was designed by clinicians and is supported by a case management system and(More)
Measuring the reusability of Object-Oriented (OO) program code is important to ensure a successful and timely adaptation and integration of the reused code in new software projects. It has become even more relevant with the availability of huge amounts of open-source projects. Reuse saves cost, increases the speed of development and improves software(More)
Component-Based Software Development is a promise that was made in 1968 during the NATO symposium, where “software engineering” term is said to have originated. Since then, the ideal state of software development as an engineering discipline is “assembling instead of programming”. However, even today, we seem to be quite far from this ideal. The Enterprise(More)
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