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The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into interdisciplinary scientific research, and promoting the achievement of(More)
Key Words and Phrases: ill-posed problems; partial thin plate smoothing splines; penalized likelihood ; semi-parametric models; ridge regression; thin plate smoothing splines; truncated singular value decomposition. Purpose These Fortran-77 subroutines provide building blocks for Generalized Cross-Validation (GCV) (Craven and Wahba, 1979) calculations in(More)
This paper is intended to introduce those familiar with database management issues to the problems of managing large statistical databases. We begin with a characterization of statistical databases based on the structure and use of the data in the database. Several data management problems are then described. In particular, we discuss the problem of(More)
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