Douglas L. Forrester

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Matrix metalloproteinases (MMPs) are elevated in the airways and blood of COPD patients, contributing to disease pathogenesis and tissue remodelling. However, it is not clear if MMP levels in airways, blood and urine are related or if MMP levels are related to disease severity or presence of exacerbations requiring hospitalisation. Seventy-two patients(More)
BACKGROUND Pulmonary P. aeruginosa infection is associated with poor outcomes in cystic fibrosis (CF) and early diagnosis is challenging, particularly in those who are unable to expectorate sputum. Specific P. aeruginosa 2-alkyl-4-quinolones are detectable in the sputum, plasma and urine of adults with CF, suggesting that they have potential as biomarkers(More)
Pseudomonas aeruginosa produces quorum sensing signal molecules that are potential biomarkers for infection.A prospective study of 60 cystic fibrosis patients with chronic P. aeruginosa, who required intravenous antibiotics for pulmonary exacerbations, was undertaken. Clinical measurements and biological samples were obtained at the start and end of the(More)
BACKGROUND sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) is a novel inflammatory marker that may be of clinical use in cystic fibrosis (CF). Dysregulation of the TREM pathway has been demonstrated in other inflammatory diseases and modulation in animal models has therapeutic benefit. We hypothesised that sTREM-1 could act as a biomarker(More)
It is over 20 years since the discovery of interleukin-5 (IL5) and the demonstration of its role as an eosinophil differentiation and chemotactic factor [1, 2]. A few years before the discovery of IL-5, the evidence supporting the importance of the eosinophil in the pathogenesis of bronchial asthma was beginning to mount [3]. Initially reported as an(More)
importance of prenatal exposures on the development of allergic disease: a birth cohort study using the West Midlands general practice database. Umbilical cord trace elements and minerals and risk of early childhood wheezing and eczema. Antioxidant intake in pregnancy in relation to wheeze and eczema in the first two years of life. Low maternal vitamin E(More)
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