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BACKGROUND Epithelial cell adhesion molecule is overexpressed in bladder tumours and released from bladder cancer cells in vitro. We test the hypotheses that urinary EpCAM could act as a biomarker for primary bladder cancer detection and risk stratification. METHODS Epithelial cell adhesion molecule was measured by ELISA in urine from 607 patients with(More)
Colorectal cancer (CRC) is often diagnosed at a late stage with concomitant poor prognosis. Early detection greatly improves prognosis; however, the invasive, unpleasant and inconvenient nature of current diagnostic procedures limits their applicability. No serum-based test is currently of sufficient sensitivity or specificity for widespread use. In the(More)
Helper-dependent (HD), high-capacity adenoviruses are one of the most efficient and safe gene therapy vectors, capable of mediating long-term expression. Currently, the most widely used system for HD vector production avoids significant contamination with helper virus by using producer cells stably expressing a nuclear-targeted Cre recombinase and an(More)
We determined the isoforms of tropomyosin expressed and the level of tropomyosin phosphorylation in donor, end-stage failing and hypertrophic obstructive cardiomyopathy samples of human heart muscle. Western blots and isoform-specific antibodies showed that α-tropomyosin was the only significant isoform expressed and that tropomyosin was 25–30 %(More)
In the urethane-anesthetized rat both electrical stimulation (20 microA, 0.2 ms, 30 s) through micropipettes and glutamate injections (0.1 M, 100 nl) within an area including the dorsal lateral parabrachial nucleus, the adjacent central lateral parabrachial nucleus, the external lateral parabrachial nucleus, the Kölliker-Fuse nucleus, and the adjacent(More)
Arterial pressure normally changes very little during small hemorrhage. In cats with bilateral lesions of the region of the caudal periaqueductal gray arterial pressure and renal vascular resistance decreased rapidly and precipitously during a 10 ml/kg X 3 min-1 hemorrhage. This lack of compensation was pronounced in response to a hemorrhage one week after(More)
Basal mean arterial pressure (MAP) measured one week following placement of pontine lesions was markedly lower (-27.85 mm Hg) in cats with bilateral lesions of the caudal periaqueductal gray than in cats with bilateral lesions of the area anteroventral to the locus coeruleus. Regression models of the relationship between basal arterial pressure (MAPbasal)(More)