Douglas G. Lampard

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Control of a number of interactive physiological variables by an online computer, operating in real time, is demonstrated. It is shown that a computer-controlled system, by monitoring values of arterial blood pressure, end-tidal CO2 percentage and inspired O2 percentage, can maintain the respiration and anaesthesia of a ventialted animal within close(More)
Following 5 minutes of global ischemia, local cerebral blood flow (LCBF) was shown to have an initial reactive hyperemia that was followed, within the first hour, by persistent hypoperfusion (Part I). Intracranial pressure (ICP) was never elevated during the period of poor reperfusion. These experiments attempted to reverse the state of subnormal LCBF by(More)
Using the hydrogen clearance technique, local cerebral blood flow (LCBF) in 22 dogs was estimated at 6 parietal sites prior to and following 5 min of total global ischemia. Ischemia was immediately followed by an initial reactive hyperemia during which the electrocorticogram (ECoG) usually began to recover, and within the first 30 min, most of the LCBF's(More)
Computer control of anaesthesia has been extended to include muscle relaxant drugs. Injection of d-tubocurarine, gallamine, alcuronium or pancuronium was controlled by computer to reduce the integrated electromyogram to a preset level (40 per cent of control) for one hour. A programmed level of muscle paralysis is therefore possible for use in physiological(More)
Paralysis was maintained in sheep by computer-controlled infusion of atracurium, using the integrated electromyogram as a measure of neuromuscular transmission. A number of experiments were conducted to ascertain the average infusion rate required to achieve a given level of paralysis for one hour. Each experiment yielded a point on a plot of paralysis(More)
There exists a good correlation between the measured electrical activities and isometric twitch tension in the cat soleus muscle during synchronous stimulation. For an unbiased sampling of electrical activities by averaging a number of electromyograms over the muscle concerned, a relation of the form E = 0.98T + 5.35 has been established. It is hoped that(More)