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The Oak Ridge Leadership Computing Facility (OLCF) has deployed multiple large-scale parallel file systems (PFS) to support its operations. During this process, OLCF acquired significant expertise in large-scale storage system design, file system software development, technology evaluation, benchmarking, procurement, deployment, and operational practices.(More)
The Spider system at the Oak Ridge National Labo-ratory's Leadership Computing Facility (OLCF) is the world's largest scale Lustre parallel file system. Envisioned as a shared parallel file system capable of delivering both the bandwidth and capacity requirements of the OLCF's diverse computational environment, the project had a number of ambitious goals.(More)
BACKGROUND Geographic profiling is a statistical tool originally developed in criminology to prioritise large lists of suspects in cases of serial crime. Here, we use two data sets--one historical and one modern--to show how it can be used to locate the sources of infectious disease. RESULTS First, we re-analyse data from a classic epidemiological study,(More)
Anopheles arabiensis is a particularly opportunistic feeder and efficient vector of Plasmodium falciparum in Africa and may invade areas outside its normal range, including areas separated by expanses of barren desert. The purpose of this paper is to demonstrate how spatial models can project future irrigated cropland and potential, new suitable habitat for(More)
Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the(More)
The Middle East North Africa (MENA) region is under continuous threat of the re-emergence of West Nile virus (WNV) and Rift Valley Fever virus (RVF), two pathogens transmitted by the vector species Culex pipiens. Predicting areas at high risk for disease transmission requires an accurate model of vector distribution, however, most Cx. pipiens distribution(More)
BACKGROUND Anopheles albimanus is among the most important vectors of human malaria in Mesoamerica and the Caribbean Basin (M-C). Here, we use topographic data and 1950-2000 climate (near present), and future climate (2080) layers obtained from general circulation models (GCMs) to project the probability of the species' presence, p(s), using the species(More)
With malaria control in Latin America firmly established in most countries and a growing number of these countries in the pre-elimination phase, malaria elimination appears feasible. A review of the literature indicates that malaria elimination in this region will be difficult without locally tailored strategies for vector control, which depend on more(More)
We analyzed trends in time series of the normalized difference vegetation index (NDVI) from multitemporal satellite imagery for 2001–2010 over the southeastern Everglades where major changes in vegetation structure and type have been associated with sea-level rise and reduced freshwater flow since the 1940s. Non-parametric trend analysis using the Theil-Sen(More)
Changes in land use and land cover (LULC) as well as climate are likely to affect the geographic distribution of malaria vectors and parasites in the coming decades. At present, malaria transmission is concentrated mainly in the Amazon basin where extensive agriculture, mining, and logging activities have resulted in changes to local and regional hydrology,(More)