Douglas F Willson

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BACKGROUND Septic shock is a heterogeneous syndrome within which probably exist several biological subclasses. Discovery and identification of septic shock subclasses could provide the foundation for the design of more specifically targeted therapies. Herein we tested the hypothesis that pediatric septic shock subclasses can be discovered through(More)
OBJECTIVE After prolonged opioid exposure, children develop opioid-induced hyperalgesia, tolerance, and withdrawal. Strategies for prevention and management should be based on the mechanisms of opioid tolerance and withdrawal. PATIENTS AND METHODS Relevant manuscripts published in the English language were searched in Medline by using search terms(More)
OBJECTIVE A systematic review of weaning and extubation for pediatric patients on mechanical ventilation. DATA SELECTION Pediatric and adult literature, English language. STUDY SELECTION Invited review. DATA SOURCES Literature review using National Library of Medicine PubMed from January 1972 until April 2008, earlier cross-referenced article(More)
OBJECTIVES Nosocomial infection/sepsis occurs in up to 40% of children requiring long-term intensive care. Zinc, selenium, glutamine, metoclopramide (a prolactin secretalogue), and/or whey protein supplementation have been effective in reducing infection and sepsis in other populations. We evaluated whether daily nutriceutical supplementation with zinc,(More)
OBJECTIVE To evaluate whether a formula could be derived using oxygen saturation (Spo2) to replace Pao2 that would allow identification of children with acute lung injury and acute respiratory distress syndrome. Definitions of acute lung injury and acute respiratory distress syndrome require arterial blood gases to determine the Pao2/Fio2 ratio of 300(More)
OBJECTIVE To investigate the extent of complicated grief symptoms and associated risk factors among parents whose child died in a pediatric intensive care unit. DESIGN Cross-sectional survey conducted by mail and telephone. SETTING Seven children's hospitals affiliated with the Collaborative Pediatric Critical Care Research Network from January 1, 2006,(More)
OBJECTIVES Randomized clinical trials are commonly overseen by a Data and Safety Monitoring Board comprised of experts in medicine, ethics, and biostatistics. Data and Safety Monitoring Board responsibilities include protocol approval, interim review of study enrollment, protocol compliance, safety, and efficacy data. Data and Safety Monitoring Board(More)
OBJECTIVES Abusive head trauma is a leading cause of traumatic death and disability during infancy and early childhood. Evidence-based screening tools for abusive head trauma do not exist. Our research objectives were 1) to measure the predictive relationships between abusive head trauma and isolated, discriminating, and reliable clinical variables and 2)(More)
The study by Sun et al 1 in this issue of RESPIRATORY CARE, comparing high-frequency oscillatory ventilation (HFOV) and conventional mechanical ventilation, merits close attention because it is one of few studies demonstrating clear benefit from HFOV, relative to conventional mechanical ventilation, in preterm infants. In the study, 336 preterm infants(More)
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