Douglas F Willson

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BACKGROUND Septic shock is a heterogeneous syndrome within which probably exist several biological subclasses. Discovery and identification of septic shock subclasses could provide the foundation for the design of more specifically targeted therapies. Herein we tested the hypothesis that pediatric septic shock subclasses can be discovered through(More)
There is a widely acknowledged problem of drug abuse in the United States, but there is no widely accepted estimate of the number who need treatment for drug abuse. In this article, the authors present new estimates of the numbers of persons in this country who need and receive treatment. These estimates are derived from improved definitions and statistical(More)
Objective: To evaluate whether a formula could be derived using oxygen saturation (Spo 2) to replace Pao 2 that would allow identification of children with acute lung injury and acute respiratory distress syndrome. Definitions of acute lung injury and acute respiratory distress syndrome require arterial blood gases to determine the Pao 2 /Fio 2 ratio of 300(More)
BACKGROUND Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill(More)
The study by Sun et al 1 in this issue of RESPIRATORY CARE, comparing high-frequency oscillatory ventilation (HFOV) and conventional mechanical ventilation, merits close attention because it is one of few studies demonstrating clear benefit from HFOV, relative to conventional mechanical ventilation, in preterm infants. In the study, 336 preterm infants(More)
Identification of pediatric septic shock subclasses based on genome-wide expression profiling. Abstract Background: Septic shock is a heterogeneous syndrome within which probably exist several biological subclasses. Discovery and identification of septic shock subclasses could provide the foundation for the design of more specifically targeted therapies.(More)
This paper presents preliminary research carried out at CIRANO and aims to encourage discussion and comment. The observations and viewpoints expressed are the sole responsibility of the authors. They do not necessarily represent positions of CIRANO or its partners. CIRANO Le CIRANO est une corporation privée à but non lucratif constituée en vertu de la Loi(More)
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