Douglas F. Hacking

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Dyslexia is one of the most prevalent childhood cognitive disorders, affecting approximately 5% of school-age children. We have recently identified a risk haplotype associated with dyslexia on chromosome 6p22.2 which spans the TTRAP gene and portions of THEM2 and KIAA0319. Here we show that in the presence of the risk haplotype, the expression of the(More)
Harlequin Ichthyosis (HI) is a severe and often lethal hyperkeratotic skin disease caused by mutations in the ABCA12 transport protein. In keratinocytes, ABCA12 is thought to regulate the transfer of lipids into small intracellular trafficking vesicles known as lamellar bodies. However, the nature and scope of this regulation remains unclear. As part of an(More)
combinations, and identified those genes specifically involved in the disease and minimizing variations between samples and different cell cultures. The comparison between control and NSCL/P patients yielded 56 genes. Subsequent signaling pathway analyses involving the identified genes, suggested involvement of three different pathways. In particular, we(More)
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