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MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer.
It is suggested that microRNA profiling of circulating tumor exosomes could potentially be used as surrogate diagnostic markers for biopsy profiling, extending its utility to screening asymptomatic populations.
Exosomal microRNA: a diagnostic marker for lung cancer.
The significant difference in total exosome and miRNA levels between lung cancer patients and controls, and the similarity between the circulating exosomal miRNAs and the tumor-derived miRNA patterns, suggest that circulating exOSomal miRNA might be useful as a screening test for lung adenocarcinoma.
Exosome isolation for proteomic analyses and RNA profiling.
While the existence of exosomes has been known for over three decades, they have garnered recent interest due to their potential diagnostic and therapeutic relevance. The expression and release of
Specific Isolation of Placenta‐Derived Exosomes from the Circulation of Pregnant Women and Their Immunoregulatory Consequences 1
In normal pregnancy, as factors linked with early immunomodulation decline, placental exosomes become critical in modulating T‐cell activation, suppressing effector T cells by enhancing lymphocyte apoptosis and CD3‐zeta loss.
Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes.
Sera of patients with active oral squamous cell carcinoma contain FasL+ microvesicles, which induce the receptor and mitochondrial apoptotic pathways in Jurkat and activated T cells, and correlated with the patients' tumor burden and nodal involvement.
Pregnancy-Associated Exosomes and Their Modulation of T Cell Signaling1
It is demonstrated that exosomes from pregnancies ultimately delivering at term are present at significantly greater concentrations than those from pregnancies delivering preterm; however, exosome from term-delivering pregnancies also exhibit significantly greater suppression of CD3-ζ and JAK3.
Identifying mRNA, MicroRNA and Protein Profiles of Melanoma Exosomes
The results indicate that melanoma-derived exosomes have unique gene expression signatures, miRNA and proteomics profiles compared to exosome from normal melanocytes, which is the first in-depth screening of the whole transcriptome/miRNome/proteome expression in melanomaExosomes.
Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments
Tumor exosomes of tumor origin can be found within neoplastic lesions and in biologic fluids from cancer patients, implying a potential role of these pathways in in vivo tumor progression and systemic paraneoplastic syndromes.
The origin, function, and diagnostic potential of RNA within extracellular vesicles present in human biological fluids
Tumor-derived extracellular vesicles express components responsible for angiogenesis promotion, stromal remodeling, signal pathway activation through growth factor/receptor transfer, chemoresistance, and genetic exchange and their presence in the peripheral circulation may serve as a surrogate for tumor biopsies, enabling real-time diagnosis and disease monitoring.
Nanoparticle analysis of circulating cell-derived vesicles in ovarian cancer patients.
It is demonstrated that NTA can measure the size distributions of cell-derived vesicles comparable to other analysis instrumentation, and the use of fluorescent-labeled antibodies against specific markers with NTA allows the determination of the "phenotype" of the cell- derived vesicle concentration.