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Pathologic angiogenesis mediated by abnormally polarized macrophages plays a central role in common age-associated diseases such as atherosclerosis, cancer, and macular degeneration. Here we demonstrate that abnormal polarization in older macrophages is caused by programmatic changes that lead to reduced expression of ATP binding cassette transporter ABCA1.(More)
A total of 82 feed manufacturers located within seven midwestern states (Iowa, Nebraska, Minnesota, Illinois, Indiana, Ohio, Michigan) participated in a survey of mold and mycotoxin contamination of corn. Samples were submitted from a composite of the grading samples taken from each incoming load of corn. The survey was initiated in July 1988. During the(More)
Autophagy is an important component of host innate and adaptive immunity to viruses. It is critical for the degradation of intracellular pathogens and for promoting antigen presentation. Herpes simplex virus type 1 (HSV-1) infection induces an autophagy response, but this response is antagonized by the HSV-1 neurovirulence gene product, ICP34.5. This is(More)
The prevalence of coronary heart disease (CHD) risk factors in law enforcement personnel compared to that in the general population was studied by determining the predicted 10-year risk for developing CHD (CHD10, expressed as %) in subjects from the Iowa Department of Public Safety and comparing it to the average CHD10 for similarly aged subjects in the(More)
Necropsy of 13 agalactic and 11 normally lactating sows at 1 to 2 days after parturition revealed that 7 of the agalactic and 4 of the clinically normal sows had lesions of mastitis. Escherichia coli, Streptococcus equisimilis, and Staphylococcus epidermidis were the predominant organisms isolated. The organisms were isolated as pure and as mixed cultures(More)
Cross-cultural comparisons of categorization often confound cultural factors with expertise. This paper reports four experiments on the conceptual behavior of Native American and majority-culture fish experts. The two groups live in the same general area and engage in essentially the same set of fishing-related behaviors. Nonetheless, cultural differences(More)
Hourly milk yields were obtained for nine consecutive hours at d 14 of lactation from 92 crossbred (four breed) sows during their first and second lactations. Additionally, milk yields were obtained at d 14 and 20 of lactation from 175 mature Yorkshire X Landrace sows for nine consecutive hours. Each measurement (4,806 observations) was obtained by weighing(More)