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BACKGROUND The W-curve was originally developed as a graphical visualization technique for viewing DNA and RNA sequences. Its ability to render features of DNA also makes it suitable for computational studies. Its main advantage in this area is utilizing a single-pass algorithm for comparing the sequences. Avoiding recursion during sequence alignments(More)
The high mutation rate in HIV-1 makes it difficult to treat and analyze. Monitoring the evolution of drug resistance requires frequent re-sequencing, but comparing and visualizing the progress is difficult. One difficulty is simply locating the areas of interest: gaps and crossover mutations make it difficult to isolate clinically significant sequences for(More)
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