Douglas Bowman

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Aurora A is a serine/threonine protein kinase essential for normal mitotic progression. Aberrant increased expression of Aurora A, which occurs frequently in human cancers, results in abnormal mitoses leading to chromosome instability and possibly tumorigenesis. Consequently, Aurora A has received considerable attention as a potential target for anticancer(More)
Aurora A kinase plays an essential role in the proper assembly and function of the mitotic spindle, as its perturbation causes defects in centrosome separation, spindle pole organization, and chromosome congression. Moreover, Aurora A disruption leads to cell death via a mechanism that involves aneuploidy generation. However, the link between the immediate(More)
Normal human esophageal autopsy tissue was explanted in serum-free medium. The epithelial outgrowths were subcultured and then transfected by strontium phosphate coprecipitation with plasmid pRSV-T consisting of the RSV-LTR promoter and the sequence encoding the simian virus 40 large T-antigen. The transfected cells, but not the sham-transfected controls,(More)
Let a, b, c, d be complex numbers with d 6= 0 and |q| < 1. Define H1(a, b, c, d, q) := 1 1 + −abq + c (a + b)q + d + · · · + −abq + cq (a + b)qn+1 + d + · · · . We show that H1(a, b, c, d, q) converges and 1 H1(a, b, c, d, q) − 1 = c − abq d + aq P∞ j=0 (b/d)(−c/bd)j q (q)j(−aq/d)j P∞ j=0 (b/d)(−c/bd)j q (q)j(−aq/d)j . We then use this result to deduce(More)
This paper is an intensive study of the convergence of the Rogers-Ramanujan continued fraction. Let the continued fraction expansion of any irrational number t ∈ (0, 1) be denoted by [0, a1(t), a2(t), · · · ] and let the i-th convergent of this continued fraction expansion be denoted by ci(t)/di(t). Let S = {t ∈ (0, 1) : ai+1(t) ≥ φi infinitely often},(More)
We prove some new evaluations for multiple polylogarithms of arbitrary depth. The simplest of our results is a multiple zeta evaluation one order of complexity beyond the well-known Broadhurst-Zagier formula. Other results we provide settle three of the remaining outstanding conjectures of Borwein, Bradley, and Broadhurst [4]. A complete treatment of a(More)